Shenzhen Key Laboratory of Smart Healthcare Engineering, Department of Biomedical Engineering, Southern University of Science and Technology, No. 1088 Xueyuan Rd, Nanshan District, Shenzhen, Guangdong 518055, China.
GBA Research Innovation Institute for Nanotechnology, CAS Key Lab for Biological Effects of Nanomaterials and Nanosafety, National Center for NanoScience and Technology, Beijing 100190, China.
Nano Lett. 2022 May 11;22(9):3576-3582. doi: 10.1021/acs.nanolett.1c04968. Epub 2022 Apr 29.
Nanomaterials usually kill bacteria via multiple mechanisms which are not explicit to the same degree as those of conventional antibiotics. This situation may hinder the development of novel nanoscale antibiotics. Here, we present aminophenol (AP) to modify gold nanoparticles (AP_Au NPs) which show a broad antibacterial spectrum and potent antibacterial effects against multidrug-resistant (MDR) bacteria with clear antibacterial mechanisms. AP_Au NPs can not only damage bacterial cell walls but also bind to the 16S rRNA to block bacterial protein synthesis. Moreover, AP_Au NPs show excellent performance in curing abdominal bacterial infections in an model. AP_Au NPs thus have the potential to become a novel antibacterial agent for clinical applications.
纳米材料通常通过多种机制杀死细菌，这些机制并不像传统抗生素那样明确。这种情况可能会阻碍新型纳米级抗生素的发展。在这里，我们提出了氨基酚（AP）来修饰金纳米粒子（AP_Au NPs），它们显示出广谱的抗菌谱和对多药耐药（MDR）细菌的强大抗菌作用，具有明确的抗菌机制。AP_Au NPs 不仅可以破坏细菌细胞壁，还可以与 16S rRNA 结合，阻止细菌蛋白质合成。此外，AP_Au NPs 在治疗腹部细菌感染的模型中表现出优异的性能。因此，AP_Au NPs 有可能成为一种用于临床应用的新型抗菌剂。
