College of Chemistry, South China Normal University, Guangzhou 510006, People's Republic of China.
Key Laboratory of Organofluorine Chemistry Shanghai Institute of Organic Chemistry Chinese Academy of Sciences, China.
Org Biomol Chem. 2022 Feb 16;20(7):1532-1537. doi: 10.1039/d1ob02349g.
We report for the first time the coupling of activated thioamides with alcohols to efficiently form thionoesters a palladium-catalyzed C-N cleavage strategy. The new approach employs thioamides as a thioacylating reagent to give thionoesters in moderate to good yields. Notably, this methodology demonstrates a broad substrate scope, as alkyl/aryl alcohols are well tolerated, and this process might facilitate the synthesis of sulfur-containing compounds under simple and mild conditions.
我们首次报道了通过钯催化的 C-N 键断裂策略，将活化的硫代酰胺与醇有效地偶联形成硫代酯。这种新方法采用硫代酰胺作为硫代酰化试剂，以中等至良好的收率得到硫代酯。值得注意的是，该方法表现出广泛的底物范围，因为烷基/芳基醇具有良好的耐受性，并且该过程可能在简单温和的条件下促进含硫化合物的合成。
