Wu Yingying, Wang Ruike, Liu Rundong, Ba Yue, Huang Hui
Department of Environmental Health, College of Public Health, Zhengzhou University, Henan province, Zhengzhou, 450001, China.
Biol Trace Elem Res. 2023 Jan;201(1):31-40. doi: 10.1007/s12011-022-03134-5. Epub 2022 Feb 7.
Increasing research is illuminating the intricate roles of metal ions in neural development as well as neurological disorders, which may stem from misregulation or dysfunction of epigenetic modifiers. Lead (Pb), cadmium (Cd), aluminum (Al), and arsenic were chosen for critical review because they have become serious public health concerns due to globalization and industrialization. In this review, we will introduce various modes of action of metals and consider the role of two posttranslational modifications: histone acetylation and methylation and how each of them affects gene expression. We then summarize the findings from previous studies on the neurological outcomes and histone alterations in response to the metals on each of the previously described histone modifications mechanisms. Understanding metal-induced histone modifications changes could provide better insight on the mechanism through which neurotoxicity occurs, to propose and validate these modifications as possible biomarkers for early identification of neurological damage, and can help model targeted therapies for the diseases of the brain.
越来越多的研究揭示了金属离子在神经发育以及神经疾病中所起的复杂作用，这些疾病可能源于表观遗传修饰因子的调控异常或功能障碍。由于全球化和工业化，铅（Pb）、镉（Cd）、铝（Al）和砷已成为严重的公共卫生问题，因此被选为重点综述对象。在本综述中，我们将介绍金属的各种作用方式，并探讨两种翻译后修饰的作用：组蛋白乙酰化和甲基化，以及它们各自如何影响基因表达。然后，我们总结了以往关于上述每种组蛋白修饰机制对金属反应的神经学结果和组蛋白改变的研究发现。了解金属诱导的组蛋白修饰变化，有助于更深入地了解神经毒性发生的机制，提出并验证这些修饰作为早期识别神经损伤的可能生物标志物，并有助于为脑部疾病建立靶向治疗模型。
