Graduate Program in Interactive Processes of Organs and Systems, Health Sciences Institute, Federal University of Bahia, Salvador, Brazil.
Adventist College of Bahia, Department of Dentistry, Cachoeira, Brazil.
Phytother Res. 2022 Mar;36(3):1115-1125. doi: 10.1002/ptr.7378. Epub 2022 Feb 7.
The objective of this study was to evaluate the effect of topical chamomile in the prevention and/or treatment of oral mucositis (OM) in cancer patients. It was a systematic review, which sought articles of the randomized clinical trial according to the PRISMA parameters, registered in the PROSPERO. The databases used were PubMed, Cochrane Library, and Bireme. Descriptors were selected from DeCs/MeSH and the PICO strategy was applied. The search found 148 publications. After all the steps, six articles were selected. The total sample included 492 patients and all studies used the same OM measurement scale. The results showed that the application of topical chamomile was effective in the prevention and/or treatment of OM in four of the six studies, with a dose ranging from 1% to 2.5% and duration that ranged from single to 4 times a day. Some limitations were observed: the minimum age of the patients was not informed, and there was no specification of the sites involved or the chemotherapies used. The application of topical chamomile in the preventive/therapeutic of chemo-induced OM seems to be recommended. In addition, scientific production should be encouraged, as it aims to determine useful protocols for this phytotherapy for the oncology population.
本研究旨在评估局部应用洋甘菊预防和/或治疗癌症患者口腔粘膜炎（OM）的效果。这是一项系统评价，根据 PRISMA 标准，按照 PROSPERO 进行了随机临床试验的检索。使用的数据库是 PubMed、Cochrane 图书馆和 Bireme。从 DeCs/MeSH 中选择了描述词，并应用了 PICO 策略。搜索共找到了 148 篇出版物。经过所有步骤，最终选择了 6 篇文章。总样本包括 492 名患者，所有研究都使用了相同的 OM 测量量表。结果显示，在 6 项研究中的 4 项中，局部应用洋甘菊在预防和/或治疗 OM 方面是有效的，剂量范围为 1%至 2.5%，使用频率从每天 1 次到 4 次不等。观察到一些局限性：未报告患者的最小年龄，也未说明涉及的部位或使用的化疗药物。局部应用洋甘菊预防/治疗化疗引起的 OM 似乎是可行的。此外，应该鼓励科学研究，以确定这种植物疗法对肿瘤患者的有用方案。
