在艾姆斯沙门氏菌/微粒体试验中5-羟甲基脱氧尿苷与5-取代2'-脱氧尿苷类似物的致突变活性比较。
Comparison of the mutagenic activity of 5-hydroxymethyldeoxyuridine with 5-substituted 2'-deoxyuridine analogs in the Ames Salmonella/microsome test.
作者信息
Bilimoria M H, Gupta S V
出版信息
Mutat Res. 1986 Mar;169(3):123-7. doi: 10.1016/0165-1218(86)90091-1.
PMID:3512995
Abstract
4 antiviral drugs 5-hydroxymethyldeoxyuridine (HMUdR), 5-trifluorothymidine (F3TdR), 5-methoxymethyldeoxyuridine (MMUdR) and 5-ethyldeoxyuridine (EtUdR) have been evaluated for mutagenic activity in the Ames Salmonella/microsome test. The antimetabolites F3TdR and HMUdR were mutagenic in a dose-dependent manner in strain TA100. F3TdR also was mutagenic in strain TA1535. Rat-liver post-mitochondrial supernatant (S9) was not required for mutagenicity.
摘要
已在艾姆斯沙门氏菌/微粒体试验中评估了4种抗病毒药物5-羟甲基脱氧尿苷（HMUdR）、5-三氟胸苷（F3TdR）、5-甲氧基甲基脱氧尿苷（MMUdR）和5-乙基脱氧尿苷（EtUdR）的致突变活性。抗代谢物F3TdR和HMUdR在TA100菌株中呈剂量依赖性致突变。F3TdR在TA1535菌株中也具有致突变性。致突变性不需要大鼠肝脏线粒体后上清液（S9）。
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