在特定位点合成含有5-（羟甲基）-2'-脱氧尿苷的寡核苷酸。
Synthesis of Oligonucleotides Containing 5-(Hydroxymethyl)-2'-deoxyuridine at Defined Sites.
作者信息
Sowers Lawrence C, Beardsley G Peter
机构信息
Division of Pediatrics, City of Hope National Medical Center, 1500 East Duarte Road, Duarte, California 91010, and Departments of Pediatrics and Pharmacology, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut 06510.
出版信息
J Org Chem. 1993;58(7):1664-1665. doi: 10.1021/jo00059a011.
Abstract
A method is described for the solid-phase synthesis of oligonucleotides containing the DNA oxidation damage product, 5-(hydroxymethyl)-2'-deoxyuridine (HMdU) at selected sites using a phosphoramidite synthon regiospecifically protected on the 5-(hydroxymethyl) group.
摘要
描述了一种用于在选定位点固相合成含有DNA氧化损伤产物5-(羟甲基)-2'-脱氧尿苷(HMdU)的寡核苷酸的方法，该方法使用在5-(羟甲基)基团上进行区域特异性保护的亚磷酰胺合成子。
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本文引用的文献
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Ionizing radiation and tritium transmutation both cause formation of 5-hydroxymethyl-2'-deoxyuridine in cellular DNA.电离辐射和氚嬗变都会导致细胞DNA中形成5-羟甲基-2'-脱氧尿苷。
Proc Natl Acad Sci U S A. 1984 Jan;81(2):318-21. doi: 10.1073/pnas.81.2.318.
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Synthesis and biological activities of 5-(hydroxymethyl, azidomethyl, or aminomethyl)-2'-deoxyuridine and related 5'-substituted analogues.5-（羟甲基、叠氮甲基或氨甲基）-2'-脱氧尿苷及相关5'-取代类似物的合成与生物活性
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In vitro and in vivo studies of a promising antileukemic thymidine analogue, 5-hydroxymethyl-2' deoxyuridine.一种有前景的抗白血病胸苷类似物5-羟甲基-2'-脱氧尿苷的体外和体内研究。
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Genetic effects of 5-hydroxymethyl-2'-deoxyuridine, a product of ionizing radiation.电离辐射产物5-羟甲基-2'-脱氧尿苷的遗传效应。
Mutat Res. 1987 Jun;178(2):177-86. doi: 10.1016/0027-5107(87)90267-3.
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