Sowers Lawrence C, Beardsley G Peter
Division of Pediatrics, City of Hope National Medical Center, 1500 East Duarte Road, Duarte, California 91010, and Departments of Pediatrics and Pharmacology, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut 06510.
J Org Chem. 1993;58(7):1664-1665. doi: 10.1021/jo00059a011.
A method is described for the solid-phase synthesis of oligonucleotides containing the DNA oxidation damage product, 5-(hydroxymethyl)-2'-deoxyuridine (HMdU) at selected sites using a phosphoramidite synthon regiospecifically protected on the 5-(hydroxymethyl) group.
描述了一种用于在选定位点固相合成含有DNA氧化损伤产物5-(羟甲基)-2'-脱氧尿苷(HMdU)的寡核苷酸的方法，该方法使用在5-(羟甲基)基团上进行区域特异性保护的亚磷酰胺合成子。
