Absence of mutagenic activity of ticlopidine in the Ames Salmonella/microsome test.
作者信息
Hannuniemi R, Sellman R
出版信息
Mutat Res. 1985 Oct-Nov;158(1-2):31-3. doi: 10.1016/0165-1218(85)90094-1.
PMID:3900717
Abstract
Ticlopidine hydrochloride, 5-(o-chlorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine hydrochloride, a platelet aggregation inhibitor, was tested for mutagenic activity in the Ames Salmonella/mammalian microsome test. Salmonella typhimurium strains TA98, TA100, TA1535, TA1537 and TA1538 were employed. Two of these strains (TA1535 and TA100) are sensitive to base-pair substitution mutagens, and the remaining 3 are sensitive to frame-shift mutagens. There was no evidence that ticlopidine hydrochloride had any mutagenic activity either in the presence or absence of a liver microsomal supplement.
摘要
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