Margolis-Nunno H, Schreibman M P, Halpern-Sebold L
Department of Biology, Brooklyn College, City University of New York 11210.
Mech Ageing Dev. 1987 Nov;41(1-2):139-48. doi: 10.1016/0047-6374(87)90058-3.
Somatostatin (SRIF) was localized by immunocytochemistry in the brains and pituitary glands of male and female platyfish (Xiphophorus maculatus) between the ages of 8 and 30 months (average life span is 30 months). In the brain, immunoreactive (ir-) SRIF is found in the perikarya of the ventrobasal hypothalamus (nucleus lateralis tuberis, nucleus anterior tuberis), dorsomedial hypothalamus, dorsal thalamus, ventral tegmentum and rhombencephalic basal plate; in the pituitary it is localized surrounding the ir-growth hormone containing cells of the caudal pars distalis, and in older fish it is also found within certain cells of the pars intermedia. We have demonstrated that there are consistent, sexually dimorphic, age-related changes in the intensity and/or distribution of ir-SRIF. The sexual dimorphism of the changes in SRIF immunoreactivity during the aging of platyfish may be related to the different patterns of growth observed in males and females.
采用免疫细胞化学方法，对8至30月龄（平均寿命为30个月）的雄性和雌性剑尾鱼（Xiphophorus maculatus）的脑和垂体中的生长抑素（SRIF）进行了定位。在脑中，免疫反应性（ir-）SRIF存在于腹侧基底下丘脑（外侧结节核、前结节核）、背内侧下丘脑、背侧丘脑、腹侧被盖区和菱脑基板的神经细胞体中；在垂体中，它定位于尾侧远侧部含ir-生长激素细胞的周围，在较年长的鱼中，还可在中间部的某些细胞中发现。我们已经证明，ir-SRIF的强度和/或分布存在一致的、与性别相关的、与年龄有关的变化。剑尾鱼衰老过程中SRIF免疫反应性变化的性别二态性可能与雄性和雌性观察到的不同生长模式有关。
