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神经移植:科学进展与临床前景

Neural transplantation: scientific gains and clinical perspectives.

作者信息

Fishman P S

出版信息

Neurology. 1986 Mar;36(3):389-92. doi: 10.1212/wnl.36.3.389.

DOI:10.1212/wnl.36.3.389
PMID:3513048
Abstract

Neural transplantation, once deemed impossible, is being studied in many laboratories. Embryonic CNS from a variety of sites can be grafted into an adult host. The foreign cells differentiate and then produce neurotransmitters or neurohormones. Physical connection can be seen between graft and host. Grafting of fetal tissue may be followed by improved function of animals with experimental forms of neurologic disease or physical injury. Grafted segments of peripheral nerve become innervated by central axons that can conduct physiologic impulses. Grafted glial cells can form myelin within the CNS. Therapeutic grafting into the human nervous system may be feasible, but many scientific and ethical questions remain to be addressed.

摘要

神经移植,曾经被认为是不可能的,现在正在许多实验室进行研究。来自各种部位的胚胎中枢神经系统可以移植到成年宿主中。外来细胞分化后会产生神经递质或神经激素。可以看到移植物与宿主之间存在物理连接。将胎儿组织移植到患有实验性神经疾病或身体损伤的动物体内后,其功能可能会得到改善。移植的外周神经节段会被能够传导生理冲动的中枢轴突所支配。移植的神经胶质细胞可以在中枢神经系统内形成髓鞘。将其治疗性地移植到人类神经系统中可能是可行的,但许多科学和伦理问题仍有待解决。

相似文献

1
Neural transplantation: scientific gains and clinical perspectives.神经移植:科学进展与临床前景
Neurology. 1986 Mar;36(3):389-92. doi: 10.1212/wnl.36.3.389.
2
Co-transplantation of fetal or adult dorsal root ganglia and of autologous peripheral nerve segments to the adult rat spinal cord: extensive reinnervation of the grafted nerves by the transplanted DRG cells.
Dev Neurosci. 1992;14(2):123-9. doi: 10.1159/000111656.
3
Neural repair of the injured spinal cord by grafting: comparison between peripheral nerve segments and embryonic homologous structures as a conduit of CNS axons.通过移植进行脊髓损伤的神经修复:周围神经节段与胚胎同源结构作为中枢神经系统轴突导管的比较
Neurosci Res. 1998 Jul;31(3):241-9. doi: 10.1016/s0168-0102(98)00042-x.
4
Grafting of neural tissue in chronically injured spinal cord: influence of the donor tissue on regenerative activity.慢性损伤脊髓中神经组织的移植:供体组织对再生活性的影响。
Surg Neurol. 2000 Aug;54(2):117-25. doi: 10.1016/s0090-3019(00)00287-1.
5
Neural tissue grafts and repair of the injured spinal cord.神经组织移植与脊髓损伤修复
Neuropathol Appl Neurobiol. 1985 Mar-Apr;11(2):81-104. doi: 10.1111/j.1365-2990.1985.tb00007.x.
6
Experimental repair of spinal cord lesions by grafting from CNS to PNS.
J Reconstr Microsurg. 1988 Jul;4(4):245-50. doi: 10.1055/s-2007-1006927.
7
Reinnervation of the biceps brachii muscle following cotransplantation of fetal spinal cord and autologous peripheral nerve into the injured cervical spinal cord of the adult rat.将胎儿脊髓与自体周围神经共同移植到成年大鼠损伤的颈脊髓后肱二头肌的再支配。
Exp Neurol. 2001 Feb;167(2):329-40. doi: 10.1006/exnr.2000.7556.
8
[Reconstruction of the spinal cord and its motor connections using embryonal nervous tissue transplantation and peripheral nerve autotransplantation. A study in the adult rat].[使用胚胎神经组织移植和周围神经自体移植重建脊髓及其运动连接。对成年大鼠的研究]
Neurochirurgie. 1991;37(5):303-11.
9
Intracerebral neural grafting.脑内神经移植
Neurol Psychiatr (Bucur). 1988 Jul-Sep;26(3):135-52.
10
Transplantation into the mammalian CNS: a meeting report on the sixth Schmitt neurological sciences symposium.向哺乳动物中枢神经系统的移植:第六届施密特神经科学研讨会会议报告
Neurobiol Aging. 1988 Jan-Feb;9(1):127-37. doi: 10.1016/s0197-4580(88)80040-x.

引用本文的文献

1
Hippocampal neurons transplanted into ischemically lesioned hippocampus: electroresponsiveness and reestablishment of circuitries.
Exp Brain Res. 1989;76(2):333-42. doi: 10.1007/BF00247893.
2
Hippocampal neurons transplanted into ischemically lesioned hippocampus: anatomical assessment of survival, maturation and integration.移植到缺血性损伤海马体中的海马神经元:存活、成熟和整合的解剖学评估
Exp Brain Res. 1991;86(2):233-47. doi: 10.1007/BF00228948.