Christie M J, Beart P M, Jarrott B, Maccarrone C
Neurosci Lett. 1986 Jan 30;63(3):305-9. doi: 10.1016/0304-3940(86)90375-7.
The distribution of neuropeptide Y-like immunoreactivity (NPY-LI) within the rat basal ganglia was studied using microdissection with a sensitive radioimmunoassay, and excitotoxin lesions were made in an attempt to characterise the neurones containing NPY in this brain area. Immunoreactivity was unevenly distributed in the basal ganglia of control rats, with concentrations in the caudate-putamen (CP) and nucleus accumbens being appreciably higher than those found in the globus pallidus and substantia nigra (SN). Within the CP, immunoreactivity was concentrated in caudal and extreme rostral aspects. N-Methyl-D-aspartate lesions of the rostral CP significantly reduced immunoreactivity in this area, whilst levels in other regions of the basal ganglia were unaffected. Neurones containing NPY-LI are likely to be intrinsic to the CP and do not appear to project to the globus pallidus or SN.
采用显微解剖和灵敏放射免疫分析法，研究了大鼠基底神经节内神经肽Y样免疫反应性（NPY-LI）的分布，并制作了兴奋性毒素损伤，试图对该脑区中含NPY的神经元进行表征。免疫反应性在对照大鼠的基底神经节中分布不均，尾状核-壳核（CP）和伏隔核中的浓度明显高于苍白球和黑质（SN）中的浓度。在CP内，免疫反应性集中在尾部和最前端。吻侧CP的N-甲基-D-天冬氨酸损伤显著降低了该区域的免疫反应性，而基底神经节其他区域的水平未受影响。含NPY-LI的神经元可能是CP固有的，似乎不投射到苍白球或SN。
