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儿童多系统炎症综合征（MIS-C）的临床特征及推测病因：综述

Clinical aspects and presumed etiology of multisystem inflammatory syndrome in children (MIS-C): A review.

作者信息

Kundu Anusrita, Maji Swagata, Kumar Suchismita, Bhattacharya Shreya, Chakraborty Pallab, Sarkar Joy

机构信息

Department of Botany, Bethune College, Manicktala, Kolkata, West Bengal, 700006, India.

Department of Botany, Acharya Prafulla Chandra College, New Barrakpur, Kolkata, West Bengal, 700131, India.

出版信息

Clin Epidemiol Glob Health. 2022 Mar-Apr;14:100966. doi: 10.1016/j.cegh.2022.100966. Epub 2022 Feb 3.

DOI:10.1016/j.cegh.2022.100966
PMID:35132389
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8810427/
Abstract

The COVID-19 outbreak sparked by SARS-CoV-2, begat significant rates of malady worldwide, where children with an abnormal post-COVID ailment called the Multisystem Inflammatory Syndrome (MIS-C), were reported by April 2020. Here we have reviewed the clinical characteristics of the pediatric patients and the prognosis currently being utilized. A vivid comparison of MIS-C with other clinical conditions has been done. We have addressed the probable etiology and fundamental machinery of the inflammatory reactions, which drive organ failure. The involvement of androgen receptors portrays the likelihood of asymptomatic illness in children below adolescence, contributing to the concept of antibody-dependent enhancement.

摘要

由严重急性呼吸综合征冠状病毒2（SARS-CoV-2）引发的2019冠状病毒病（COVID-19）疫情在全球范围内导致了很高的发病率，到2020年4月，已有患有一种名为多系统炎症综合征（MIS-C）的COVID后异常疾病的儿童病例报告。在此，我们回顾了儿科患者的临床特征以及目前所采用的预后情况。我们对MIS-C与其他临床病症进行了清晰的比较。我们探讨了引发器官衰竭的炎症反应的可能病因和基本机制。雄激素受体的参与表明青春期前儿童出现无症状疾病的可能性，这有助于理解抗体依赖增强的概念。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a96a/8810427/7a5b0b97e036/gr2_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a96a/8810427/c3e473bf8fb5/gr1_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a96a/8810427/7a5b0b97e036/gr2_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a96a/8810427/c3e473bf8fb5/gr1_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a96a/8810427/7a5b0b97e036/gr2_lrg.jpg

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