Department of Neuropsychiatry, Dongguk University Ilsan Hospital, Goyang, Korea.
Department of Biomedical Engineering, Ulsan National Institute of Science and Technology, Ulsan, Korea.
J Korean Med Sci. 2022 Feb 7;37(5):e34. doi: 10.3346/jkms.2022.37.e34.
The purpose of this longitudinal prospective cohort study was to investigate the role of chronotype in the incidence of chemotherapy-induced peripheral neuropathy (CIPN) among women with breast cancer.
We recruited women with breast cancer awaiting adjuvant chemotherapy, including four cycles of docetaxel. Participants reported peripheral neuropathy symptoms of numbness/tingling at the baseline, and at 4weeks after completion of chemotherapy. Candidate psychiatric factors associated with CIPN were assessed at the baseline, using the Composite Scale of Morningness, the Pittsburgh Sleep Quality Index, and the Hospital Anxiety and Depression Scale. To examine the association between chronotype and CIPN, we built logistic regression models, adjusting for demographic, clinical, and other psychiatric variables.
Among 48 participants, 29 participants developed CIPN. The morning chronotype was inversely associated with CIPN (odds ratio, 0.06; confidence interval, 0.01-0.74; = 0.028) after adjusting for age, BMI, education, type of operation, alcohol use, smoking, sleep quality, depression, and anxiety.
Our results suggest that the morning chronotype is a protective factor against the development of CIPN in patients with breast cancer who were treated with docetaxel.
ClinicalTrials.gov Identifier: NCT01887925.
本纵向前瞻性队列研究旨在探讨时型在乳腺癌女性接受化疗引起的周围神经病变（CIPN）发生率中的作用。
我们招募了等待辅助化疗的乳腺癌女性，包括四个周期的多西他赛。参与者在基线时和化疗结束后 4 周报告麻木/刺痛等周围神经病变症状。使用综合晨间型量表、匹兹堡睡眠质量指数和医院焦虑抑郁量表在基线时评估与 CIPN 相关的候选精神因素。为了研究时型与 CIPN 之间的关系，我们建立了逻辑回归模型，调整了人口统计学、临床和其他精神变量。
在 48 名参与者中，有 29 名参与者出现 CIPN。在调整年龄、BMI、教育程度、手术类型、饮酒、吸烟、睡眠质量、抑郁和焦虑后，晨型与 CIPN 呈负相关（比值比，0.06；95%置信区间，0.01-0.74；P=0.028）。
我们的结果表明，在接受多西他赛治疗的乳腺癌患者中，晨型是 CIPN 发展的保护因素。
ClinicalTrials.gov 标识符：NCT01887925。
