Waalen K, Duff G W, Førre O, Dickens E, Kvarnes L, Nuki G
Scand J Immunol. 1986 Mar;23(3):365-71. doi: 10.1111/j.1365-3083.1986.tb01977.x.
Dendritic cells (DC) from the synovial inflammatory tissue and peripheral blood of patients with rheumatoid arthritis and from the peripheral blood of normal blood donors were compared with the autologous monocytes for their capacity to produce and release interleukin 1 (IL-1). Synovial DC often spontaneously released higher amounts of IL-1 activity than unstimulated and lipopolysaccharide-stimulated peripheral blood DC and monocytes. The IL-1 production by both DC and monocytes increased after stimulation with bacterial lipopolysaccharide. In contrast with synovial DC the peripheral blood DC from both patients with rheumatoid arthritis and normal controls released less IL-1 activity than peripheral blood monocytes did. Inhibition with an antiserum to IL-1 revealed that IL-1 production is important for the accessory activity of the peripheral blood DC. Thus human DC from inflammatory sites and peripheral blood produce IL-1 activity.
将类风湿性关节炎患者滑膜炎症组织和外周血中的树突状细胞（DC）以及正常献血者外周血中的树突状细胞，与自体单核细胞产生和释放白细胞介素1（IL-1）的能力进行了比较。滑膜DC通常比未刺激的和脂多糖刺激的外周血DC及单核细胞自发释放更高量的IL-1活性。用细菌脂多糖刺激后，DC和单核细胞的IL-1产生均增加。与滑膜DC相反，类风湿性关节炎患者和正常对照的外周血DC释放的IL-1活性低于外周血单核细胞。用抗IL-1抗血清抑制表明，IL-1产生对外周血DC的辅助活性很重要。因此，来自炎症部位和外周血的人DC产生IL-1活性。
