School of Chemical Sciences, Central University of Gujarat, Gandhinagar 382030, India.
J Org Chem. 2022 Mar 4;87(5):2410-2420. doi: 10.1021/acs.joc.1c02307. Epub 2022 Feb 8.
A mild, greener approach toward thioamide synthesis has been developed. Its unique features include water-mediated reaction with no input energy, additives, or catalysts as well. The presented protocol is attractive with readily available starting materials and the use of different array amines, along with a scaled-up method. Biologically active molecules such as thionicotinamide and thioisonicotinamide can be synthesized from this procedure.
已经开发出一种温和、绿色的硫酰胺合成方法。其独特之处还包括在没有输入能量、添加剂或催化剂的情况下用水介导的反应。该方案具有吸引力，因为它使用了易于获得的起始原料和不同的芳基胺，以及一种放大方法。可以通过该方法合成生物活性分子，如硫代烟酰胺和硫代异烟酰胺。
