State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, 38 Xueyuan Road, Beijing 100191, China.
Org Lett. 2010 Sep 17;12(18):4066-9. doi: 10.1021/ol101644g.
A simple and efficient method for the synthesis of 1,3,4-trisubstituted or 3,4-disubstituted pyrroles has been developed. The reaction represents the first time that pyrroles are synthesized directly from readily available aldehydes and amines (anilines) as starting materials. This method has been successfully applied to the rapid synthesis of purpurone.
开发了一种简单高效的合成 1,3,4-三取代或 3,4-二取代吡咯的方法。该反应首次实现了直接以易得的醛和胺（苯胺）为起始原料合成吡咯。该方法已成功应用于紫罗酮的快速合成。
