眼底自发荧光在评估糖尿病黄斑水肿治疗反应中的应用。

Fundus autofluorescence in the evaluation of diabetic macular edema treatment response.

机构信息

Retina Department, Clínica David, Morelia, Michoacán.

Facultad de Medicina "Dr. Ignacio Chávez", Universidad Michoacana de "San Nicolás de Hidalgo", Morelia, Michoacán.

出版信息

Gac Med Mex. 2021;157(4):397-403. doi: 10.24875/GMM.M21000581.

DOI:10.24875/GMM.M21000581

PMID:35133337

Abstract

INTRODUCTION

Fundus autofluorescence (FAF) has shown sensitivity in the detection of macular edema.

OBJECTIVES

To evaluate indices formed with FAF and retinal anatomical-functional variables in patients with diabetic macular edema (DME) treated with ziv-aflibercept (ziv-AFL).

METHODS

Twenty-nine eyes of 15 DME patients who received ziv-AFL intravitreal injections were included in the study. Best-corrected visual acuity (BCVA), contrast sensitivity (CS), optical coherence tomography (OCT) and FAF were evaluated before treatment and at one and two months. OCT variables were central subfield thickness (CST), macular volume (MV) and macular cube average thickness (MCAT). FAF/BCVA, FAF/CS, FAF/CST, FAF/MV and AF/MCAT indices baseline values were obtained. Analysis was performed with Spearman's rank correlation coefficient and linear regression analysis.

RESULTS

There was a significant correlation between baseline FAF/BCVA index and BCVA at second month (r = - 0.78, p = 0.000), between baseline FAF/CS index and BCVA at second month (r = -0.68, p = 0.0009) and between baseline FAF/CS index and MV at first month of follow-up (r = 0.64, p = 0.002).

CONCLUSIONS

In DME, composite indices with baseline FAF predict variables such as BCVA in the follow-up of patients receiving ziv-AFL.

摘要

简介

眼底自发荧光（FAF）在检测黄斑水肿方面具有敏感性。

目的

评估接受 Ziv-阿柏西普（ziv-AFL）治疗的糖尿病性黄斑水肿（DME）患者的 FAF 和视网膜解剖功能变量形成的指标。

方法

本研究纳入了 15 名 DME 患者的 29 只眼，这些患者接受了 ziv-AFL 玻璃体腔内注射。在治疗前以及治疗后 1 个月和 2 个月，评估最佳矫正视力（BCVA）、对比敏感度（CS）、光学相干断层扫描（OCT）和 FAF。OCT 变量包括中央视网膜神经纤维层厚度（CST）、黄斑体积（MV）和黄斑立方平均厚度（MCAT）。获得 FAF/BCVA、FAF/CS、FAF/CST、FAF/MV 和 FAF/MCAT 指数的基线值。进行 Spearman 秩相关系数和线性回归分析。

结果

基线 FAF/BCVA 指数与第 2 个月的 BCVA 之间存在显著相关性（r = -0.78，p = 0.000），基线 FAF/CS 指数与第 2 个月的 BCVA 之间存在显著相关性（r = -0.68，p = 0.0009），以及基线 FAF/CS 指数与第 1 个月随访时的 MV 之间存在显著相关性（r = 0.64，p = 0.002）。