Henan International Collaborative Laboratory for Health Effects and Intervention of Air Pollution, School of Public Health, Xinxiang Medical University, 601 Jinsui Road, Xinxiang, 453003, China; Reproductive Center, Henan Provincial Peoples Hospital, Zhengzhou, 450003, China.
Henan International Collaborative Laboratory for Health Effects and Intervention of Air Pollution, School of Public Health, Xinxiang Medical University, 601 Jinsui Road, Xinxiang, 453003, China.
Chemosphere. 2022 May;295:133805. doi: 10.1016/j.chemosphere.2022.133805. Epub 2022 Feb 5.
Environmental exposure to metals, including essential and nonessential elements, may be related to semen quality. Our goal was to explore the continuous relationship between seminal metals and sperm parameters. A restricted cubic spline (RCS) was applied to automatic selection criteria to ascertain the optimal smoothing degree. We recruited 841 male volunteers from Henan Province, China. Eighteen seminal metals, namely Al, Cr, Mn, Cu, Zn, Se, As, Ni, Cd, Pb, Co, V, Rb, Ag, Ba, TI, Fe, and Li, and 21 semen parameters were detected. Seminal malondialdehyde (MDA) was also detected to express oxidative stress. We revealed a non-linear relationship of the vanadium and chromium exposure to semen parameters. There were inverse 'U' shapes found between seminal Cr and sperm concentrations, total sperm count, and semen quality. The best semen quality was observed when the seminal Cr concentration was 5.05 ppb, and an increase or decrease in chromium concentration led to decreased semen quality. The V concentration was associated with reduced sperm concentration, total sperm count, normal morphology, and progressive motility at high doses (V > 0.58 ppb). Seminal MDA had a strong adverse association with sperm motility parameters, such as curve line velocity (VCL) (P < 0.001), straight line velocity (VSL) (P = 0.004), velocity of average path (VAP) (P < 0.001), and lateral head movement (ALH) (P = 0.001), whereas it was adversely associated with seminal Zn (β [95% confidence interval (CI)], -0.28(-0.41-0.16), P < 0.001) after adjusting for confounding factors. Our findings represent the curves of the dose-response relationship between seminal Cr, seminal V, and semen quality, in which seminal MDA was a good indicator of sperm movement. These models provide new insight into the dose-relationship between metal exposure and semen quality, and further investigation is needed to validate this.
环境暴露于金属，包括必需和非必需元素，可能与精液质量有关。我们的目标是探索精液金属与精子参数之间的连续关系。应用限制立方样条（RCS）进行自动选择标准，以确定最佳平滑度。我们从中国河南省招募了 841 名男性志愿者。检测了 18 种精液金属，即 Al、Cr、Mn、Cu、Zn、Se、As、Ni、Cd、Pb、Co、V、Rb、Ag、Ba、TI、Fe 和 Li，以及 21 种精液参数。还检测了精液丙二醛（MDA）以表达氧化应激。我们揭示了钒和铬暴露与精液参数之间的非线性关系。发现精液中 Cr 与精子浓度、总精子数和精液质量之间存在反“U”形关系。当精液 Cr 浓度为 5.05 ppb 时，观察到最佳精液质量，而 Cr 浓度的增加或减少都会导致精液质量下降。高剂量（V>0.58 ppb）时，V 浓度与精子浓度、总精子数、正常形态和前向运动能力降低有关。精液 MDA 与精子运动参数如曲线速度（VCL）（P<0.001）、直线速度（VSL）（P=0.004）、平均路径速度（VAP）（P<0.001）和侧向头部运动（ALH）（P=0.001）呈强烈负相关，而在调整混杂因素后，与精液 Zn 呈负相关（β[95%置信区间（CI）]，-0.28（-0.41-0.16），P<0.001）。我们的研究结果代表了精液 Cr、精液 V 与精液质量之间的剂量-反应关系曲线，其中精液 MDA 是精子运动的良好指标。这些模型为金属暴露与精液质量之间的剂量关系提供了新的见解，需要进一步研究来验证这一点。
