Sun Jianyun, Gui Chunyan, Xiao Ya, Ma Runxue, Liu Ce, He Li, Zhao Hao, Luo Bin
Gansu Provincial Centre for Diseases Prevention and Control, Lanzhou 730000, China.
Institute of Occupational Health and Environmental Health, School of Public Health, Lanzhou University, Lanzhou 730000, China.
Toxics. 2024 Mar 18;12(3):222. doi: 10.3390/toxics12030222.
While mounting evidence suggests a connection between environmental contaminants and sleep problems, it remains uncertain whether exposure to volatile organic compounds (VOCs) specifically is associated with such problems.
Data from the National Health and Nutrition Examination Survey program's five survey cycles (2005-2006, 2011-2018) were used to conduct cross-sectional research. Data on short sleep duration (SSD) and self-reported trouble sleeping were collected from questionnaire data. Data on urine VOCs were gathered from laboratory data. The association between urinary VOCs and sleep problems was examined using weighted generalized linear models and the restricted cubic spline (RCS), weighted quantile sum (WQS), and quantile-based g-calculation (QGC) methods.
In all, a total of 4131 general adult individuals were included in this study. The prevalence of SSD and self-reported trouble sleeping was 34.11% and 25.03%, respectively. 3,4-MHA, AAMA, AMCC, SBMA, and MA were risk factors for SSD after adjusting several covariates, with the largest effect being AMCC (OR = 1.47, 95% CI: 1.08, 2.02). Risk factors for sleep issues included AAMA, AMCC, CEMA, CYMA, DGBMA, 2HPMA, 3HPMA, MA, and PGA, with AMCC having the highest impact with an OR of 1.69 (95% CI: 1.28, 2.22). Both the WQS model and the QGC model showed that the co-exposure to VOCs was positively associated with SSD and self-reported trouble sleeping, with AMCC being the most influential VOC.
According to our research, high levels of single or mixed urine VOCs are linked to a higher prevalence of SSD and self-reported trouble sleeping in the general adult population of the United States. Further prospective and experimental studies are needed in the future to validate these potential relationships and explore the underlying mechanisms.
虽然越来越多的证据表明环境污染物与睡眠问题之间存在联系，但接触挥发性有机化合物（VOCs）是否具体与这些问题相关仍不确定。
利用国家健康与营养检查调查计划五个调查周期（2005 - 2006年、2011 - 2018年）的数据进行横断面研究。从问卷数据中收集短睡眠时间（SSD）和自我报告的睡眠问题数据。从实验室数据中收集尿液VOCs数据。使用加权广义线性模型以及受限立方样条（RCS）、加权分位数和（WQS）和基于分位数的g计算（QGC）方法检查尿液VOCs与睡眠问题之间的关联。
本研究共纳入4131名一般成年个体。SSD和自我报告的睡眠问题的患病率分别为34.11%和25.03%。在调整了几个协变量后，3,4 - MHA、AAMA、AMCC、SBMA和MA是SSD的危险因素，影响最大的是AMCC（OR = 1.47，95% CI：1.08，2.02）。睡眠问题的危险因素包括AAMA、AMCC、CEMA、CYMA、DGBMA、2HPMA、3HPMA、MA和PGA，其中AMCC影响最大，OR为1.69（95% CI：1.28，2.22）。WQS模型和QGC模型均显示，VOCs的共同暴露与SSD和自我报告的睡眠问题呈正相关，AMCC是最有影响力的VOC。
根据我们的研究，在美国一般成年人群中，高水平的单一或混合尿液VOCs与SSD和自我报告的睡眠问题的较高患病率相关。未来需要进一步的前瞻性和实验研究来验证这些潜在关系并探索潜在机制。
