高龄人群的基底节钙化与精神症状

Basal ganglia calcification and psychotic symptoms in the very old.

作者信息

Ostling Svante, Andreasson Lars Arne, Skoog Ingmar

机构信息

The Sahlgrenska Academy AT Göteborg University, Institute of Clinical Neuroscience, Psychiatry Section, Unit for Neuropsychiatric Epidemiology, Sahlgrenska University Hospital, Göteborg, Sweden.

出版信息

Int J Geriatr Psychiatry. 2003 Nov;18(11):983-7. doi: 10.1002/gps.997.

DOI:10.1002/gps.997

PMID:14618548

Abstract

BACKGROUND

Basal ganglia calcification (BGC) is associated with psychotic symptoms in young and middle-aged patient samples.

METHODS

We studied the cross-sectional relationship between psychotic symptoms and BGC in a population sample of non-demented 85-year-olds, of whom 86 were mentally healthy, 11 had hallucinations or delusions, 21 had mood disorders and 20 had anxiety disorders. BGC was measured using computerized tomography (CT). Mental disorders were diagnosed using DSM-III-R criteria and psychotic symptoms were evaluated using information from psychiatric examinations, key-informant interviews and review medical records.

RESULTS

BGC on CT was observed in 19% of mentally healthy and 64% of non-demented individuals with hallucinations or delusions [Odds Ratio (OR) 7.7, 95% Confidence Intervals (CI) 2.9-29.7, p=0.003]. There were no associations between BGC and mood or anxiety disorders.

CONCLUSIONS

BGC is strongly associated with psychotic symptoms in very old age, possibly due to a disturbance in the basal ganglia dopaminergic system.

摘要

背景

基底节钙化（BGC）与中青年患者样本中的精神症状相关。

方法

我们在一个85岁非痴呆人群样本中研究了精神症状与BGC之间的横断面关系，其中86人心理健康，11人有幻觉或妄想，21人有情绪障碍，20人有焦虑障碍。使用计算机断层扫描（CT）测量BGC。根据《精神疾病诊断与统计手册》第三版修订版（DSM-III-R）标准诊断精神障碍，并通过精神病学检查、关键 informant 访谈和查阅病历信息评估精神症状。