Department of Oral and Maxillofacial Medicine, Kerman University of Medical Sciences, Kerman, Iran.
Department of Oral and Maxillofacial Medicine, Semnan University of Medical Sciences, Semnan, Iran.
J Ethnopharmacol. 2022 May 23;290:115037. doi: 10.1016/j.jep.2022.115037. Epub 2022 Feb 5.
In modern medicine, some traditional remedies are introduced to be effective in treatment. Accordingly, the henna plant (Lawsonia inermis L.) is studied more than before. Previous studies have shown many medical properties for henna, such as anti-inflammatory and anti-fungal properties.
Oral lichen planus (OLP) is a common mucocutaneous disease with chronic immunomodulatory disruptions. Topical corticosteroids are the first line of OLP treatment. Previous studies have suggested different adjunctive therapies for preventing the side effects of corticosteroids overuse. This study aimed to compare the effects of henna and chlorhexidine mouthwashes as adjunctive therapy.
This parallel-group, double-blind, randomized controlled study was conducted on forty OLP patients. Luteolin content was determined in Henna mouthwash composed of 2% aqueous extract of henna, 2% ethanol, 10% glycerol, and 0.1% methylparaben distilled water. Henna or chlorhexidine mouthwashes were prescribed twice daily as an adjuvant to the topical corticosteroid treatment. Visual analog scale (VAS) index and Thongprasom rating were used to measure pain intensity and clinical signs of patients at days 0,7, and 14. The collected data were analyzed using SPSS software (version 26.0; SPSS). Ordinal logistic regression was used to investigate the effect of independent variables on Thongprasom and VAS scores.
In this clinical trial, 82.6% of the participants were women. There was no difference between the two study groups in terms of VAS scores (p = 0.404) and clinical features (p = 0.305) in the second follow-up visit. All drug regimens caused clinical signs and symptoms relief.
There was no significant difference between the groups receiving topical corticosteroid supplementation, neither henna mouthwash nor chlorhexidine mouthwash. The therapeutic effects of henna mouthwash in the main or adjuvant treatment of OLP need more evaluation in future research. Henna mouthwash can be a good alternative to chlorhexidine mouthwash if no side effects are reported.
在现代医学中，一些传统疗法被引入并被证明在治疗中有效。因此，指甲花植物（指甲花）的研究比以前更加深入。先前的研究表明指甲花具有许多医学特性，如抗炎和抗真菌特性。
口腔扁平苔藓（OLP）是一种常见的黏膜皮肤疾病，具有慢性免疫调节紊乱。局部皮质类固醇是 OLP 治疗的一线药物。先前的研究表明，有不同的辅助疗法可预防皮质类固醇过度使用的副作用。本研究旨在比较指甲花和洗必泰漱口液作为辅助治疗的效果。
这是一项平行组、双盲、随机对照研究，共纳入 40 例 OLP 患者。指甲花漱口液由 2%指甲花水提取物、2%乙醇、10%甘油和 0.1%对羟基苯甲酸甲酯蒸馏水组成。将指甲花或洗必泰漱口液每天两次作为局部皮质类固醇治疗的辅助剂开具。在第 0、7 和 14 天，使用视觉模拟量表（VAS）指数和 Thongprasom 评分来测量患者的疼痛强度和临床体征。使用 SPSS 软件（版本 26.0；SPSS）分析收集的数据。有序逻辑回归用于研究独立变量对 Thongprasom 和 VAS 评分的影响。
在这项临床试验中，82.6%的参与者为女性。在第二次随访时，两组患者的 VAS 评分（p=0.404）和临床特征（p=0.305）均无差异。所有药物治疗方案均能缓解临床症状和体征。
在接受局部皮质类固醇补充治疗的患者中，指甲花漱口液和洗必泰漱口液之间没有显著差异。指甲花漱口液在 OLP 的主要或辅助治疗中的治疗效果需要在未来的研究中进一步评估。如果没有报道不良反应，指甲花漱口液可以替代洗必泰漱口液。
