Herbal and Traditional Medicines Research Center, Kerman University of Medical Sciences, Kerman, Iran; Department of Traditional Medicine, Faculty of Traditional Medicine, Kerman University of Medical Sciences, Kerman, Iran.
Herbal and Traditional Medicines Research Center, Kerman University of Medical Sciences, Kerman, Iran.
Complement Ther Med. 2020 Mar;49:102316. doi: 10.1016/j.ctim.2020.102316. Epub 2020 Jan 15.
Contact dermatitis is a common complication in prosthetic limb users. There are no effective, available and cheap treatments for skin problems of these patients. In traditional Iranian medicine, henna (Lawsonia inermis L.) is a plant that has anti-inflammatory, antimicrobial and skin-enhancing properties, all of which are beneficial for people with artificial limbs. The aim of this study was to assess the efficacy of a topical henna preparation in management of contact dermatitis in patients using lower limb prosthetics.
The current randomized, double-blind, placebo-controlled clinical trial was conducted on ninety-five participants with lower extremity amputation using limb prosthetics, aged 12-70 years who complained of contact dermatitis. They were randomly assigned to receive either two weeks of topical henna preparation every night as the intervention group, or topical placebo as the control group. Participants were instructed to spread henna preparation on the surfaces of the amputated limb that were in contact with the prosthesis. Severity of contact dermatitis symptoms was set as the primary outcome measure. Edema, papules and erythema were evaluated by a physician using standard color atlas. Secondary outcomes included symptoms such as burning, itching, pain, thickness and skin sweating evaluated by a self-administered questionnaire.
A significant improvement was observed in the symptoms of contact dermatitis including skin edema, itching, sweating, skin thinning and pain (p-value<0.05) in the henna group compared to the placebo group. Skin burning decreased more in the henna group compared to the placebo group, but this was not statistically significant (p-value = 0.052). Moreover, skin redness significantly increased in the henna group (p-value = 0.001).
Topical formulation of henna might be a complementary choice for improving contact dermatitis in patients using lower limb prosthetics.
接触性皮炎是假肢使用者的常见并发症。目前尚无针对这些患者皮肤问题的有效、可用且廉价的治疗方法。在伊朗传统医学中，指甲花（指甲花 Lawsonia inermis L.）是一种具有抗炎、抗菌和增强皮肤特性的植物，所有这些特性都有益于使用假肢的人。本研究旨在评估局部指甲花制剂治疗下肢假肢使用者接触性皮炎的疗效。
本随机、双盲、安慰剂对照临床试验共纳入 95 名下肢截肢使用假肢的患者，年龄在 12-70 岁之间，他们抱怨患有接触性皮炎。他们被随机分为两组，每晚接受两周的局部指甲花制剂治疗（干预组）或局部安慰剂治疗（对照组）。参与者被指示将指甲花制剂涂抹在与假肢接触的截肢部位表面。接触性皮炎症状的严重程度作为主要结局指标。医生使用标准色图谱评估水肿、丘疹和红斑。次要结局包括烧灼感、瘙痒、疼痛、厚度和皮肤出汗等症状，通过自我管理问卷进行评估。
与安慰剂组相比，指甲花组接触性皮炎的症状（包括皮肤水肿、瘙痒、出汗、皮肤变薄和疼痛）显著改善（p 值<0.05）。与安慰剂组相比，指甲花组皮肤烧灼感有所减轻，但无统计学意义（p 值=0.052）。此外，指甲花组皮肤发红显著增加（p 值=0.001）。
局部指甲花制剂可能是改善下肢假肢使用者接触性皮炎的一种补充选择。
