Khosravi Seyed A, Kamalinejad Mohammad, Javadi Seyed M, Namdar Hasan, Fesharaki Mohammad G
From the Department of Traditional Persian Medicine, School of Persian Medicine, Shahed University, Tehran, Iran.
Department of Pharmacognosy, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Indian J Dermatol. 2025 Jul-Aug;70(4):221. doi: 10.4103/ijd.ijd_673_24. Epub 2025 Jun 30.
Wound complications associated with pilonidal sinus (PS) significantly contribute to its high post-operative morbidity. Therefore, speeding up the wound healing process after surgery can help minimize potential complications. This study investigated the effectiveness of extract (LIE) in promoting wound healing following PS surgery, given its known benefits in this area.
This randomized, double-blind, controlled clinical trial involved 60 patients with open post-operative PS wounds. Participants were randomly divided into three groups: the first group received LIE ointment treatment, the second group used phenytoin as a standard occlusive dressing method and the third group used eucerin ointment as a negative control. In all groups, the wound was cleansed with normal saline and dressed with wet gauze daily. A physician measured the length, depth and volume of the wounds on days 7, 14 and 28 post-PS surgery.
After two weeks, the LIE topical ointment significantly decreased the length and depth of the wound compared to phenytoin and eucerin ointments. Additionally, the wound volume in the LIE-treated group was substantially lower than in the other groups ( < 0.05).
The study highlighted the wound-healing properties of henna extract. The results indicate that LIE ointment can enhance the wound healing process, thereby lowering the risk of infection and complications in post-operative wounds.
藏毛窦(PS)相关的伤口并发症显著导致其术后高发病率。因此,加速术后伤口愈合过程有助于将潜在并发症降至最低。鉴于指甲花提取物(LIE)在该领域的已知益处,本研究调查了其在促进PS手术后伤口愈合方面的有效性。
这项随机、双盲、对照临床试验纳入了60例术后开放性PS伤口患者。参与者被随机分为三组:第一组接受LIE软膏治疗,第二组采用苯妥英作为标准封闭敷料方法,第三组使用优色林软膏作为阴性对照。在所有组中,伤口均用生理盐水清洗,每天用湿纱布包扎。一名医生在PS手术后第7天、第14天和第28天测量伤口的长度、深度和体积。
两周后,与苯妥英和优色林软膏相比,LIE外用软膏显著降低了伤口的长度和深度。此外,LIE治疗组的伤口体积明显低于其他组(<0.05)。
该研究突出了指甲花提取物的伤口愈合特性。结果表明,LIE软膏可促进伤口愈合过程,从而降低术后伤口感染和并发症的风险。