Maguire G P, Emirgil C
Am J Med Sci. 1986 Mar;291(3):168-74. doi: 10.1097/00000441-198603000-00005.
Twenty subjects with clinically stable asthma were treated in double-blind crossover manner with inhaled and oral metaproterenol, alone and in combination. The combination of inhaled and oral metaproterenol resulted in a greater degree of bronchodilation than either inhaled or oral alone. Inhaled metaproterenol was not associated with any significant side effects. Oral metaproterenol was associated with a small but significant increase in pulse rate and systolic blood pressure, and a small incidence of unpleasant sensations such as tremor and palpitation. Older subjects were more likely to experience the unpleasant sensations, whereas younger subjects were more likely to experience the increase in pulse rate.
20名临床哮喘病情稳定的受试者以双盲交叉方式接受吸入和口服间羟异丙肾上腺素治疗，包括单独使用及联合使用。吸入和口服间羟异丙肾上腺素联合使用所导致的支气管扩张程度大于单独使用吸入或口服药物。吸入间羟异丙肾上腺素未出现任何显著副作用。口服间羟异丙肾上腺素会导致心率和收缩压小幅但显著升高，以及出现如震颤和心悸等不适感觉的发生率较低。年长受试者更易出现这些不适感觉，而年轻受试者更易出现心率升高。
