Kennedy R H, Bourne W M, Dyer J A
Am J Ophthalmol. 1986 Mar 15;101(3):267-73. doi: 10.1016/0002-9394(86)90817-2.
From 1935 through 1982, keratoconus was newly diagnosed in a total of 64 residents (35 males and 29 females) of Olmsted County, Minnesota. There were no significant trends in incidence rates over time; the overall average annual rate was 2.0 per 100,000 population. The age-specific incidence rates were greatest in the younger groups. The incidence rates did not differ significantly by sex. On Dec. 31, 1982, the overall prevalence rate was 54.5 per 100,000 population. At the time of diagnosis, keratoconus was unilateral in 26 patients (41%) and bilateral in 38 patients (59%). Follow-up of the patients showed that survival did not differ significantly from that of the general population. The cumulative probability of survivorship without corneal transplantation for more than 20 years after diagnosis was greater than 80%.
从1935年到1982年，明尼苏达州奥尔姆斯特德县共有64名居民（35名男性和29名女性）被新诊断为圆锥角膜。发病率随时间没有显著趋势；总体平均年发病率为每10万人2.0例。年龄特异性发病率在较年轻组中最高。发病率在性别上没有显著差异。1982年12月31日，总体患病率为每10万人54.5例。在诊断时，26例患者（41%）的圆锥角膜为单侧，38例患者（59%）为双侧。对患者的随访表明，其生存率与普通人群没有显著差异。诊断后20多年未经角膜移植存活的累积概率大于80%。
