Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Illkirch, France.
Centre National de la Recherche Scientifique (CNRS), UMR 7104, Strasbourg, France.
Commun Biol. 2022 Feb 8;5(1):114. doi: 10.1038/s42003-022-03060-1.
Ubiquitylation is one of the most common post-translational modifications (PTMs) of proteins that frequently targets substrates for proteasomal degradation. However it can also result in non-proteolytic events which play important functions in cellular processes such as intracellular signaling, membrane trafficking, DNA repair and cell cycle. Emerging evidence demonstrates that dysfunction of non-proteolytic ubiquitylation is associated with the development of multiple human diseases. In this review, we summarize the current knowledge and the latest concepts on how non-proteolytic ubiquitylation pathways are involved in cellular signaling and in disease-mediating processes. Our review, may advance our understanding of the non-degradative ubiquitylation process.
泛素化是蛋白质最常见的翻译后修饰（PTMs）之一，它经常将底物靶向蛋白酶体降解。然而，它也可以导致非蛋白水解事件，这些事件在细胞过程中发挥着重要的功能，如细胞内信号转导、膜运输、DNA 修复和细胞周期。新出现的证据表明，非蛋白水解泛素化的功能障碍与多种人类疾病的发展有关。在这篇综述中，我们总结了目前关于非蛋白水解泛素化途径如何参与细胞信号转导和疾病介导过程的知识和最新概念。我们的综述可能会增进我们对非降解泛素化过程的理解。
