Wang Yaning, Wei Shuwen, Guo Shoujing, Kang Jin U
Electrical and Computer Engineering, Johns Hopkins University, 3400 North Charles Street, Baltimore, Maryland 21218, USA.
Proc SPIE Int Soc Opt Eng. 2021 Mar;11635. doi: 10.1117/12.2577847. Epub 2021 Mar 5.
Optical coherence tomography (OCT) with a robust depth-resolved attenuation compensation method for a wide range of imaging applications is proposed and demonstrated. The proposed novel OCT attenuation compensation algorithm introduces an optimized axial point spread function (PSF) to modify existing depth-resolved methods and mitigates under and overestimation in biological tissues, providing a uniform resolution over the entire imaging range. The preliminary study is implemented using A-mode numerical simulation, where this method achieved stable and robust compensation results over the entire depth of samples. The experiment results using phantoms and corneal imaging exhibit agreement with the simulation result evaluated using signal-to-noise (SNR) and contrast-to-noise (CNR) metrics.
本文提出并演示了一种用于广泛成像应用的、具有强大深度分辨衰减补偿方法的光学相干断层扫描（OCT）。所提出的新型OCT衰减补偿算法引入了优化的轴向点扩散函数（PSF）来改进现有的深度分辨方法，并减轻生物组织中的低估和高估问题，从而在整个成像范围内提供均匀的分辨率。初步研究通过A模式数值模拟实现，该方法在样品的整个深度上都获得了稳定且可靠的补偿结果。使用体模和角膜成像的实验结果与使用信噪比（SNR）和对比噪声比（CNR）指标评估的模拟结果一致。
