Lachej Nadezda, Dabkeviciene Daiva, Simiene Julija, Sabaliauskaite Rasa, Jonusiene Violeta, Brasiunas Vytautas, Sasnauskiene Ausra, Vaicekauskaite Ieva, Brasiuniene Birute, Kanopiene Daiva, Suziedelis Kestutis, Didziapetriene Janina
Clinic of Internal Diseases, Family Medicine and Oncology, Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, LT-10257 Vilnius, Lithuania.
National Cancer Institute, LT-08660 Vilnius, Lithuania.
J Oncol. 2022 Jan 30;2022:8199306. doi: 10.1155/2022/8199306. eCollection 2022.
New molecular biomarkers that could have an independent prognostic value in endometrial cancer are currently under investigation. Recently, it was suggested that genetic changes in the Notch signaling pathway could be associated with the development of endometrial carcinoma. This study aimed to determine the expression of the Notch signaling pathway components in tumour and adjacent normal uterine tissue and to evaluate their importance for the survival of uterine cancer patients. The present study was performed on uterine body samples collected from 109 patients and paired adjacent noncancerous endometrial tissue samples. Kaplan-Meier curves and Cox regression were used for survival analyses. Expression alterations of , , , , and were evaluated as independent and significant prognostic factors for uterine cancer patients.
目前正在研究可能在子宫内膜癌中具有独立预后价值的新分子生物标志物。最近,有人提出Notch信号通路的基因变化可能与子宫内膜癌的发生有关。本研究旨在确定Notch信号通路成分在肿瘤及相邻正常子宫组织中的表达,并评估它们对子宫癌患者生存的重要性。本研究对从109例患者收集的子宫体样本及配对的相邻非癌子宫内膜组织样本进行。采用Kaplan-Meier曲线和Cox回归进行生存分析。评估了 、 、 、 和 的表达改变作为子宫癌患者独立且显著的预后因素。