Kawaguchi Yoshiharu, Kitajima Isao, Yasuda Taketoshi, Seki Shoji, Suzuki Kayo, Makino Hiroto, Ujihara Yasuhiro, Ueno Tomohiro, Canh Tung Nguyen Tran, Yahara Yasuhito
Department of Orthopedic Surgery, University of Toyama, Toyama, Japan.
Clinical Laboratory Center, Toyama University Hospital, Toyama, Japan.
JB JS Open Access. 2022 Feb 4;7(1). doi: 10.2106/JBJS.OA.21.00111. eCollection 2022 Jan-Mar.
Ossification of the posterior longitudinal ligament (OPLL), characterized by ectopic new bone formation in the spinal ligament, causes neurological impairment due to narrowing of the spinal canal. However, the etiology has not been fully elucidated yet. Several biomarkers may be related to the pathogenesis of OPLL. The present study focused on the serum level of periostin, which is recognized as an important bone formation regulator.
This study included 92 patients with OPLL and 54 control patients without OPLL. For the case-control analysis, 54 age and sex-matched patients were randomly included in the OPLL group. The serum fibroblast growth factor-23 (FGF-23), creatinine, inorganic phosphate, calcium, alkaline phosphatase, and periostin levels were assessed. Furthermore, the calcium, creatinine, and inorganic phosphate levels in urine and the percentage of tubular reabsorption of phosphate were also analyzed. Moreover, the relationship between the biomarkers and the extent of OPLL was analyzed. The data were compared between patients with OPLL progression (the progression group) and without OPLL progression (the non-progression group).
The mean serum FGF-23 and periostin levels in the OPLL group were higher than that in the control group. The serum inorganic phosphate level in the OPLL group was lower than that in the control group. No correlation was found between any of the biomarkers and the extent of ossification. The serum periostin level in the progression group was higher than that in the non-progression group. No significant difference in the serum FGF-23 level was noted between the progression and non-progression groups. Moreover, no correlation was found between serum periostin and FGF-23 levels.
The serum periostin level is related to OPLL progression.
Prognostic Level III. See Instructions for Authors for a complete description of levels of evidence.
后纵韧带骨化（OPLL）的特征是脊柱韧带中出现异位新骨形成，由于椎管狭窄导致神经功能障碍。然而，其病因尚未完全阐明。几种生物标志物可能与OPLL的发病机制有关。本研究聚焦于骨膜蛋白的血清水平，骨膜蛋白被认为是一种重要的骨形成调节因子。
本研究纳入92例OPLL患者和54例无OPLL的对照患者。为进行病例对照分析，OPLL组随机纳入54例年龄和性别匹配的患者。评估血清成纤维细胞生长因子23（FGF - 23）、肌酐、无机磷酸盐、钙、碱性磷酸酶和骨膜蛋白水平。此外，还分析了尿中的钙、肌酐和无机磷酸盐水平以及磷酸盐的肾小管重吸收百分比。而且，分析了生物标志物与OPLL程度之间的关系。对有OPLL进展的患者（进展组）和无OPLL进展的患者（非进展组）的数据进行比较。
OPLL组的平均血清FGF - 23和骨膜蛋白水平高于对照组。OPLL组的血清无机磷酸盐水平低于对照组。未发现任何生物标志物与骨化程度之间存在相关性。进展组的血清骨膜蛋白水平高于非进展组。进展组和非进展组之间的血清FGF - 23水平未发现显著差异。此外，血清骨膜蛋白和FGF - 23水平之间未发现相关性。
血清骨膜蛋白水平与OPLL进展相关。
预后III级。有关证据水平的完整描述，请参阅作者指南。
