Kawaguchi Yoshiharu
Department of Orthopaedic Surgery, University of Toyama, Toyama, Japan.
Spine Surg Relat Res. 2022 Apr 12;6(3):224-232. doi: 10.22603/ssrr.2021-0229. eCollection 2022.
The ossification of the spinal ligaments (OSL) is characterized by ectopic new bone formation in the spinal ligament. However, the etiology of OSL has not yet been fully elucidated. This review paper summarizes the contents of previous reviews, introduces recent advances in the study of OSL and discusses future perspectives. A review of the literature that investigated the biomarkers involved in OPLL was published in 2019. The review cited 11 reports in which a calcium phosphate metabolism marker, bone turnover markers, sclerostin, dickkopf-1, secreted frizzled-related protein-1, fibroblast growth factor-23, fibronectin, menatetrenone, leptin, pentosidine, and hypersensitive C-reactive protein were examined as markers. Data published in 2021 noted that non-coding RNAs might be useful biomarkers for OSL. In addition, triglycerides, uric acid, gene expression levels of interleukin-17 receptor C, chemokine (C-X-C motif) ligand 7 (CXCL7) in the serum reportedly are biomarkers of OSL. However, several issues have been raised in previous studies. Therefore, biomarkers have yet to be conclusively investigated. Research using biomarkers is very important in clarifying pathomechanisms. Results for studies using biomarkers might also be useful for the treatment of patients with OSL in the near future.
脊柱韧带骨化（OSL）的特征是在脊柱韧带中出现异位新骨形成。然而，OSL的病因尚未完全阐明。这篇综述文章总结了以往综述的内容，介绍了OSL研究的最新进展，并讨论了未来的研究方向。2019年发表了一篇对研究OPLL相关生物标志物的文献综述。该综述引用了11篇报告，其中检测了磷酸钙代谢标志物、骨转换标志物、硬化蛋白、Dickkopf-1、分泌型卷曲相关蛋白-1、成纤维细胞生长因子-23、纤连蛋白、维生素K2、瘦素、戊糖苷和超敏C反应蛋白作为标志物。2021年发表的数据指出，非编码RNA可能是OSL的有用生物标志物。此外，据报道，血清中的甘油三酯、尿酸、白细胞介素-17受体C的基因表达水平、趋化因子（C-X-C基序）配体7（CXCL7）是OSL的生物标志物。然而，以往的研究提出了几个问题。因此，生物标志物尚未得到确凿的研究。使用生物标志物进行研究对于阐明病理机制非常重要。使用生物标志物的研究结果在不久的将来也可能对OSL患者的治疗有用。
