佛波醇12 -肉豆蔻酸酯13 -乙酸酯增强离体大鼠胰岛细胞胰高血糖素的分泌
Enhancement of glucagon secretion from isolated rat islets of Langerhans by phorbol 12-myristate 13-acetate.
作者信息
Hii C S, Stutchfield J, Howell S L
出版信息
Biochem J. 1986 Jan 1;233(1):287-9. doi: 10.1042/bj2330287.
Abstract
The phorbol ester 4 beta-phorbol 12-myristate 13-acetate (PMA), at concentrations of 0.1 microM and above, stimulated secretion of glucagon and of insulin from isolated rat islets of Langerhans incubated in the presence of 5.5 mM-glucose. Stimulation of secretion of both hormones by 1 microM-PMA persisted in the absence of external Ca2+, and could be abolished by incubating the islets at 4 degrees C. These findings suggest a role of protein kinase C in the alpha-cell (and beta-cell) secretory mechanism.
摘要
佛波酯4β-佛波醇12-肉豆蔻酸酯13-乙酸酯（PMA），浓度在0.1微摩尔及以上时，可刺激在5.5毫摩尔葡萄糖存在下孵育的离体大鼠胰岛分泌胰高血糖素和胰岛素。1微摩尔PMA对两种激素分泌的刺激在无细胞外Ca2+时仍持续存在，且将胰岛在4℃孵育可消除这种刺激。这些发现提示蛋白激酶C在α细胞（及β细胞）分泌机制中起作用。
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本文引用的文献
1
Preparation of iodine-131 labelled human growth hormone of high specific activity.
Nature. 1962 May 5;194:495-6. doi: 10.1038/194495a0.
2
Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters.
J Biol Chem. 1982 Jul 10;257(13):7847-51.
3
Calcium-activated, phospholipid-dependent protein kinase in rat pancreas islets of langerhans. Its possible role in glucose-induced insulin release.
FEBS Lett. 1982 Feb 22;138(2):183-6. doi: 10.1016/0014-5793(82)80436-5.
4
The phorbol ester TPA increases the affinity of exocytosis for calcium in 'leaky' adrenal medullary cells.
FEBS Lett. 1983 Aug 22;160(1-2):98-100. doi: 10.1016/0014-5793(83)80944-2.
5
Tumor promotor 12-O-tetradecanoylphorbol-13-acetate-induced insulin secretion: inhibition by phospholipase A2-and lipoxygenase-inhibitors.
Biochem Biophys Res Commun. 1982 Mar 30;105(2):759-65. doi: 10.1016/0006-291x(82)91499-1.
6
Synergistic effect of a tumor-promoting phorbol ester and a hypoglycemic sulfonylurea upon insulin release.
Endocrinology. 1983 Nov;113(5):1870-7. doi: 10.1210/endo-113-5-1870.
7
Phorbol diester receptor copurifies with protein kinase C.
Proc Natl Acad Sci U S A. 1983 Jan;80(1):36-40. doi: 10.1073/pnas.80.1.36.
8
The role of protein kinase C in cell surface signal transduction and tumour promotion.
Nature. 1984;308(5961):693-8. doi: 10.1038/308693a0.
9
Insulin secretion: combined effects of phorbol ester and A23187.
Biochem Biophys Res Commun. 1983 Dec 16;117(2):448-55. doi: 10.1016/0006-291x(83)91221-4.
10
Protein phosphorylation in the pancreatic B-cell.
Experientia. 1984 Oct 15;40(10):1075-84. doi: 10.1007/BF01971454.
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