佛波醇12 -肉豆蔻酸酯13 -乙酸酯增强离体大鼠胰岛细胞胰高血糖素的分泌
Enhancement of glucagon secretion from isolated rat islets of Langerhans by phorbol 12-myristate 13-acetate.
作者信息
Hii C S, Stutchfield J, Howell S L
出版信息
Biochem J. 1986 Jan 1;233(1):287-9. doi: 10.1042/bj2330287.
Abstract
The phorbol ester 4 beta-phorbol 12-myristate 13-acetate (PMA), at concentrations of 0.1 microM and above, stimulated secretion of glucagon and of insulin from isolated rat islets of Langerhans incubated in the presence of 5.5 mM-glucose. Stimulation of secretion of both hormones by 1 microM-PMA persisted in the absence of external Ca2+, and could be abolished by incubating the islets at 4 degrees C. These findings suggest a role of protein kinase C in the alpha-cell (and beta-cell) secretory mechanism.
摘要
佛波酯4β-佛波醇12-肉豆蔻酸酯13-乙酸酯（PMA），浓度在0.1微摩尔及以上时，可刺激在5.5毫摩尔葡萄糖存在下孵育的离体大鼠胰岛分泌胰高血糖素和胰岛素。1微摩尔PMA对两种激素分泌的刺激在无细胞外Ca2+时仍持续存在，且将胰岛在4℃孵育可消除这种刺激。这些发现提示蛋白激酶C在α细胞（及β细胞）分泌机制中起作用。
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