Collaboration for Outcomes Research and Evaluation (CORE), Faculty of Pharmaceutical Sciences, The University of British Columbia, Vancouver, BC, Canada.
School of Population and Public Health, The University of British Columbia, Vancouver, BC, Canada/Centre for Health Evaluation and Outcome Sciences (CHÉOS), St. Paul's Hospital, Vancouver, BC, Canada.
Mult Scler. 2022 Aug;28(9):1414-1423. doi: 10.1177/13524585211069070. Epub 2022 Feb 9.
To analyze work productivity loss and costs, including absenteeism (time missed from work), presenteeism (reduced productivity while working), and unpaid work loss, among a sample of employed people with multiple sclerosis (pwMS) in Canada, as well as its association with clinical, sociodemographic, and work-related factors.
We used cross-sectional data collected as part of the Canadian Prospective Cohort Study to Understand Progression in MS (CanProCo) and information from the Valuation of Lost Productivity questionnaire.
Among 512 pwMS who were employed, 97% showed no or mild disability and 55% experienced productivity loss due to MS in the prior 3 months. Total productivity time loss over a 3-month period averaged 60 hours (SD = 107; 23 from presenteeism, 19 from absenteeism, and 18 from unpaid work), leading to a mean cost of lost productivity of CAD$2480 (SD = 4282) per patient, with an hourly paid productivity loss greater than the wage loss. Fatigue retained significant associations with all productivity loss outcomes.
Unpaid work loss and productivity losses exceeding those of the employee alone (due to teamwork and associated factors) are key additional contributors of the high economic burden of MS. Workplace accommodations and treatments targeted at fatigue could lessen the economic impact of MS.
分析加拿大多发性硬化症（pwMS）患者劳动力生产率损失和成本，包括旷工（缺勤）、在职工作效率降低（生产力降低）和无偿工作损失，并探讨其与临床、社会人口学和工作相关因素的关系。
我们使用加拿大前瞻性队列研究来理解多发性硬化症进展（CanProCo）的数据收集部分的横断面数据和损失生产力价值评估问卷中的信息。
在 512 名就业的 pwMS 中，97%的人没有或轻度残疾，55%的人在过去 3 个月因多发性硬化症而导致生产力下降。3 个月内总生产力时间损失平均为 60 小时（标准差=107；23 小时来自在职工作效率降低，19 小时来自旷工，18 小时来自无偿工作），导致每位患者平均损失生产力成本为 2480 加元（标准差=4282），每小时的有偿生产力损失高于工资损失。疲劳与所有生产力损失结果均有显著关联。
无偿工作损失和超过员工自身（由于团队合作和相关因素）的生产力损失是多发性硬化症高经济负担的关键额外因素。针对疲劳的工作场所适应和治疗方法可以减轻多发性硬化症的经济影响。
