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通过表面配体固定化来调整金纳米团簇的近红外二区发射及其在三维生物成像中的应用。

Tailoring the SWIR emission of gold nanoclusters by surface ligand rigidification and their application in 3D bioimaging.

机构信息

Institue for Advanced Biosciences, University Grenoble Alpes, CNRS UMR5309, INSSERM U1209, Allée des Alpes 38700, La Tronche, France.

Federal Institute of Materials Research and Testing (BAM), 12489 Berlin, Germany.

出版信息

Chem Commun (Camb). 2022 Mar 1;58(18):2967-2970. doi: 10.1039/d1cc07055j.

DOI:10.1039/d1cc07055j
PMID:35137744
Abstract

The influence of solvent polarity and surface ligand rigidification on the SWIR emission profile of gold nanoclusters with an anistropic surface was investigated. A strong enhancement of the SWIR emission band at 1200 nm was observed when measuring in different local environments: in solution, in polymer composites, and in solids. SWIR imaging of mice assisted by deep learning after intravenous administration of these gold nanoclusters provides high definition pseudo-3D views of vascular blood vessels.

摘要

研究了溶剂极性和表面配体刚性化对具有各向异性表面的金纳米簇的短波近红外(SWIR)发射谱的影响。当在不同的局部环境中测量时,观察到 1200nm 处的 SWIR 发射带得到了强烈增强:在溶液中、聚合物复合材料中和固体中。静脉注射这些金纳米簇后,通过深度学习进行的小鼠 SWIR 成像提供了血管的高清晰度伪 3D 视图。

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