State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, China.
Department of Orthopedic Surgery and Orthopedic Research Institute Rehabilitation Medicine Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
Nano Lett. 2022 Feb 23;22(4):1759-1768. doi: 10.1021/acs.nanolett.1c05003. Epub 2022 Feb 9.
Severe acute pancreatitis (SAP) is an inflammatory disease of the pancreas accompanied by tissue injury and necrosis. It not only affects the pancreas but also triggers a systemic inflammatory response that leads to multiorgan failure or even death. Moreover, there is no effective treatment currently that can reverse the disease progression. In this study, tetrahedral framework nucleic acids (tFNAs) were utilized to treat SAP in mice for the first time and proved to be effective in suppressing inflammation and preventing pathological cell death. Serum levels of pancreatitis-related biomarkers witnessed significant changes after tFNAs treatment. Reduction in the expression of certain cytokines involved in local and systemic inflammatory response were observed, together with alteration in proteins related to cell death and apoptosis. Collectively, our results demonstrate that tFNAs could both alleviate SAP and its subsequent multiorgan injury in mice, thus offering a novel and effective option to deal with SAP in the future.
重症急性胰腺炎（SAP）是一种胰腺炎症性疾病，伴有组织损伤和坏死。它不仅影响胰腺，还会引发全身性炎症反应，导致多器官衰竭甚至死亡。此外，目前尚无有效的治疗方法可以逆转疾病进展。在这项研究中，首次利用四面体框架核酸（tFNAs）治疗 SAP，结果证明其在抑制炎症和防止病理性细胞死亡方面非常有效。tFNAs 治疗后，与胰腺炎相关的生物标志物的血清水平发生了显著变化。观察到与局部和全身炎症反应相关的某些细胞因子的表达减少，以及与细胞死亡和凋亡相关的蛋白质的改变。总的来说，我们的结果表明，tFNAs 既能缓解 SAP，又能减轻 SAP 后继发的多器官损伤，为未来治疗 SAP 提供了一种新的有效选择。
