在仓鼠模型中，感染获得的针对 SARS-CoV-2 Delta 变体的长期免疫力。
Long-term, infection-acquired immunity against the SARS-CoV-2 Delta variant in a hamster model.
机构信息
Influenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, WI 53711, USA.
Influenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, WI 53711, USA.
出版信息
Cell Rep. 2022 Feb 15;38(7):110394. doi: 10.1016/j.celrep.2022.110394. Epub 2022 Jan 31.
The emergence of the SARS-CoV-2 Delta variant (B.1.617.2) raises concerns about potential reduced sensitivity of the virus to antibody neutralization and subsequent vaccine breakthrough infections. Here, we use a live virus neutralization assay with sera from Pfizer- and Moderna-vaccinated individuals to examine neutralizing antibody titers against SARS-CoV-2 and observe a 3.9- and 2.7-fold reduction, respectively, in neutralizing antibody titers against the Delta variant compared with an early isolate bearing only a D614G substitution in its spike protein. We observe similar reduced sensitivity with sera from hamsters that were previously infected with an early isolate of SARS-CoV-2. Despite this reduction in neutralizing antibody titers against the Delta variant, hamsters previously infected (up to 15 months earlier) with an early isolate are protected from infection with the Delta variant, suggesting that the immune response to the first infection is sufficient to provide protection against subsequent infection with the Delta variant.
德尔塔变异株（B.1.617.2）的出现引发了人们对于该病毒对抗体中和作用敏感性降低，以及随后疫苗突破性感染可能性的担忧。在此，我们使用来自辉瑞和莫德纳疫苗接种者的血清进行活病毒中和测定，以研究针对 SARS-CoV-2 的中和抗体滴度，并观察到针对德尔塔变异株的中和抗体滴度分别降低了 3.9 倍和 2.7 倍，与仅在其刺突蛋白中具有 D614G 取代的早期分离株相比。我们还观察到用先前感染过 SARS-CoV-2 早期分离株的仓鼠血清具有类似的敏感性降低。尽管针对德尔塔变异株的中和抗体滴度降低，但先前（最多 15 个月前）感染过早期分离株的仓鼠可免受德尔塔变异株感染，表明针对初次感染的免疫反应足以提供针对随后感染德尔塔变异株的保护。
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