Department of Microbiology, Icahn School of Medicine at Mount Sinaigrid.59734.3c, New York, New York, USA.
Division of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinaigrid.59734.3c, New York, New York, USA.
mSphere. 2022 Jun 29;7(3):e0017922. doi: 10.1128/msphere.00179-22. Epub 2022 May 19.
To understand reinfection rates and correlates of protection for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), we established eight different longitudinal cohorts in 2020 under the umbrella of the PARIS (Protection Associated with Rapid Immunity to SARS-CoV-2)/SPARTA (SARS SeroPrevalence And Respiratory Tract Assessment) studies. Here, we describe the PARIS/SPARTA cohorts, the harmonized assays and analysis that are performed across the cohorts, as well as case definitions for SARS-CoV-2 infection and reinfection that have been established by the team of PARIS/SPARTA investigators. Determining reinfection rates and correlates of protection against SARS-CoV-2 infection induced by both natural infection and vaccination is of high significance for the prevention and control of coronavirus disease 2019 (COVID-19). Furthermore, understanding reinfections or infection after vaccination and the role immune escape plays in these scenarios will inform the need for updates of the current SARS-CoV-2 vaccines and help update guidelines suitable for the postpandemic world.
为了了解严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）的再感染率和保护相关性，我们在 2020 年在 PARIS（与 SARS-CoV-2 快速免疫相关的保护）/SPARTA（SARS 血清流行率和呼吸道评估）研究的框架下建立了八个不同的纵向队列。在这里，我们描述了 PARIS/SPARTA 队列、在队列之间进行的协调检测和分析，以及由 PARIS/SPARTA 研究人员团队建立的 SARS-CoV-2 感染和再感染的病例定义。确定由自然感染和疫苗接种引起的 SARS-CoV-2 感染的再感染率和保护相关性，对于 2019 年冠状病毒病（COVID-19）的预防和控制具有重要意义。此外，了解接种疫苗后的再感染或感染，以及免疫逃逸在这些情况下的作用，将为更新当前的 SARS-CoV-2 疫苗提供信息，并有助于更新适合大流行后世界的指南。
