非编码RNA在KRAS调控中的新作用
Emerging role of non-coding RNAs in the regulation of KRAS.
作者信息
Ghafouri-Fard Soudeh, Shirvani-Farsani Zeinab, Hussen Bashdar Mahmud, Taheri Mohammad, Jalili Khoshnoud Reza
机构信息
Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of Cellular and Molecular Biology, Faculty of Life Sciences and Technology, Shahid Beheshti University, Tehran, Iran.
出版信息
Cancer Cell Int. 2022 Feb 9;22(1):68. doi: 10.1186/s12935-022-02486-1.
The Kirsten ras oncogene KRAS is a member of the small GTPase superfamily participating in the RAS/MAPK pathway. A single amino acid substitution in KRAS gene has been shown to activate the encoded protein resulting in cell transformation. This oncogene is involved in the malignant transformation in several tissues. Notably, numerous non-coding RNAs have been found to interact with KRAS protein. Such interaction results in a wide array of human disorders, particularly cancers. Orilnc1, KIMAT1, SLCO4A1-AS1, LINC01420, KRAS1P, YWHAE, PART1, MALAT1, PCAT-1, lncRNA-NUTF2P3-001 and TP53TG1 are long non-coding RNAs (lncRNAs) whose interactions with KRAS have been verified in the context of cancer. miR-143, miR-96, miR-134 and miR-126 have also been shown to interact with KRAS in different tissues. Finally, circITGA7, circ_GLG1, circFNTA and circ-MEMO1 are examples of circular RNAs (circRNAs) that interact with KRAS. In this review, we describe the interaction between KRAS and lncRNAs, miRNAs and circRNAs, particularly in the context of cancer.
Kirsten 鼠肉瘤病毒癌基因KRAS是参与RAS/丝裂原活化蛋白激酶（RAS/MAPK）信号通路的小GTP酶超家族成员。KRAS基因中的单个氨基酸替换已被证明可激活编码蛋白，从而导致细胞转化。该癌基因参与多种组织的恶性转化。值得注意的是，已发现许多非编码RNA与KRAS蛋白相互作用。这种相互作用导致了多种人类疾病，尤其是癌症。Orilnc1、KIMAT1、SLCO4A1-AS1、LINC01420、KRAS1P、YWHAE、PART1、MALAT1、PCAT-1、lncRNA-NUTF2P3-001和TP53TG1是长链非编码RNA（lncRNA），它们与KRAS的相互作用已在癌症背景下得到验证。miR-143、miR-96、miR-134和miR-126也已被证明在不同组织中与KRAS相互作用。最后，circITGA7、circ_GLG1、circFNTA和circ-MEMO1是与KRAS相互作用的环状RNA（circRNA）的例子。在本综述中，我们描述了KRAS与lncRNA、miRNA和circRNA之间的相互作用，特别是在癌症背景下。
Zotero 插件