Kida H, Takeda S, Yokoyama H, Tomosugi N, Abe T, Hattori N
Clin Nephrol. 1985 Nov;24(5):221-7.
Renal biopsy specimens of 16 patients with massive proteinuria, which developed during pregnancy and had lasted as late as one month after delivery, but disappeared within 15 months were studied. Four of them disclosed focal segmental hyalinosis, sclerosis, markedly swollen and foamy endocapillary cells, and ballooning of the involved tufts. Double contour of the capillary walls, predominance of epithelial cells as well as swelling of endocapillary cells known in pre-eclampsia were also observed. Electron and immunofluorescence microscopies revealed subendothelial deposition of IgM, C3 and rather weak fibrinogen-related antigens. These results indicate that focal glomerular sclerosis may develop during pre-eclamptic pregnancy, but may follow a non-progressive clinical course after delivery.
对16例在孕期出现大量蛋白尿且持续至产后1个月但在15个月内消失的患者的肾活检标本进行了研究。其中4例显示局灶节段性玻璃样变、硬化，内皮细胞明显肿胀且呈泡沫状，受累肾小球节段呈气球样变。还观察到子痫前期中已知的毛细血管壁双轨征、上皮细胞为主以及内皮细胞肿胀。电子显微镜和免疫荧光显微镜检查显示IgM、C3及较弱的纤维蛋白原相关抗原在内皮下沉积。这些结果表明，局灶性肾小球硬化可能在子痫前期妊娠期间发生，但产后可能遵循非进行性临床病程。
