Xing Yuling, Chen Jinhu, Liu Jing, Song Guangyao, Ma Huijuan
Department of Endocrinology, Hebei General Hospital, Shijiazhuang, 050017, People's Republic of China.
Graduate School of Hebei Medical University, Shijiazhuang, 050017, People's Republic of China.
Diabetes Metab Syndr Obes. 2022 Feb 2;15:257-267. doi: 10.2147/DMSO.S350468. eCollection 2022.
To investigate the association between serum uric acid-to-creatinine ratio (SUA/Cr) and the risk of developing metabolic-associated fatty liver disease (MAFLD) in patients with type 2 diabetes mellitus (T2DM).
Overall, 1434 patients with T2DM who were admitted to Hebei General Hospital from January 2019 to December 2019 were selected as the study subjects. According to abdominal ultrasound findings, patients were divided into two groups: MAFLD group and non-MAFLD group. A total of 734 patients were diagnosed with MAFLD. Participants were divided into three study groups according to the SUA/Cr ratio. Chi-square test and one-way analysis of variance were used to perform a comparison between groups. The relationship between SUA/Cr ratio and MAFLD risk was analyzed using correlation analysis and regression analysis. Furthermore, subgroup analyses were performed to verify the robustness of the results.
The detection rate of MAFLD in patients with T2DM was 51.2%, and the detection rate of progressive liver fibrosis in T2DM patients with MAFLD was 36.6%. A significantly higher SUA/Cr ratio was seen in the MAFLD group than in the non-MAFLD group. After adjusting for confounding factors, multivariate logistic regression analysis revealed that the SUA/Cr ratio was an independent risk factor for MAFLD development. Stronger correlations were found in participants with a body mass index ranging between 23 and 28 kg/m2, HbA1C >7%, or female sex.
An elevated SUA/Cr index is independently correlated with an increased risk of MAFLD in Chinese adults with T2DM.
探讨2型糖尿病（T2DM）患者血清尿酸与肌酐比值（SUA/Cr）与发生代谢相关脂肪性肝病（MAFLD）风险之间的关联。
选取2019年1月至2019年12月在河北医科大学第一医院住院的1434例T2DM患者作为研究对象。根据腹部超声检查结果，将患者分为两组：MAFLD组和非MAFLD组。共有734例患者被诊断为MAFLD。根据SUA/Cr比值将参与者分为三个研究组。采用卡方检验和单因素方差分析进行组间比较。采用相关性分析和回归分析分析SUA/Cr比值与MAFLD风险之间的关系。此外，进行亚组分析以验证结果的稳健性。
T2DM患者MAFLD的检出率为51.2%，MAFLD的T2DM患者进展性肝纤维化的检出率为36.6%。MAFLD组的SUA/Cr比值显著高于非MAFLD组。在调整混杂因素后，多因素logistic回归分析显示SUA/Cr比值是MAFLD发生的独立危险因素。在体重指数在23至28kg/m²之间、糖化血红蛋白>7%或女性参与者中发现更强的相关性。
在中国成年T2DM患者中，SUA/Cr指数升高与MAFLD风险增加独立相关。
