Chen Bingbing, Peng Xian-E
Department of Hospital Infection Control, First Hospital of Quanzhou Affiliated to Fujian Medical University, Quanzhou, People's Republic of China.
Department of Epidemiology and Health Statistics, Fujian Provincial Key Laboratory of Environment Factors and Cancer, School of Public Health, Fujian Medical University, Fuzhou, Fujian, People's Republic of China.
Diabetes Metab Syndr Obes. 2024 Dec 8;17:4711-4720. doi: 10.2147/DMSO.S489692. eCollection 2024.
Serum uric acid to creatinine ratio (SUA/Cr) has been associated with an increased risk of metabolic syndrome; however, limited evidence exists regarding the relationship between SUA/Cr and metabolic-associated fatty liver disease (MAFLD). This study aims to investigate the association between SUA/Cr, TyG-BMI (triglyceride glucose-body mass index), and MAFLD in Chinese adults.
The data were obtained from a health examination conducted at Nanping First Hospital. Spearman correlation analysis was employed to assess the association between SUA/Cr or TyG-BMI and various risk factors pertinent to MAFLD. A multivariate logistic regression model was utilized to investigate the relationship between SUA/Cr or TyG-BMI and MAFLD. Additionally, restricted cubic splines (RCS) and receiver operating characteristic (ROC) curve analyses were applied to explore the relationship between SUA/Cr and MAFLD. Mediation models were constructed to figure out the mediating role of TyG-BMI in the association between SUA/Cr and MAFLD.
Spearman correlation analysis showed a significant association between SUA/Cr and multiple risk factors for MAFLD (such as BMI, SBP, DBP, TG, TC, ALT, AST, GGT, FPG, and HDL). Furthermore, SUA/Cr had a positive correlation with TyG-BMI (<0.05). The logistic model demonstrated that elevated levels of SUA/Cr were significantly associated with an increased risk of MAFLD, even after adjusting for confounding factors (odds ratio [OR]: 1.390; 95% confidence interval [CI]: 1.255-1.538). The RCS curves revealed a consistent and monotonic increase in the relationship between SUA/Cr levels and the occurrence of MAFLD. Moreover, SUA/Cr exhibited moderate discriminatory ability in identifying individuals with MAFLD (AUC: 0.669). Mediation analysis indicated that approximately 52.05% of the positive association between SUA/Cr and MAFLD was mediated by TyG-BMI.
Our findings suggest a substantial association between elevated levels of SUA/Cr and an increased risk of MAFLD in the Chinese adult population, with TyG-BMI mediating this correlation.
血清尿酸与肌酐比值（SUA/Cr）与代谢综合征风险增加有关；然而，关于SUA/Cr与代谢相关脂肪性肝病（MAFLD）之间关系的证据有限。本研究旨在探讨中国成年人中SUA/Cr、TyG-BMI（甘油三酯葡萄糖-体重指数）与MAFLD之间的关联。
数据来自南平第一医院进行的健康检查。采用Spearman相关性分析评估SUA/Cr或TyG-BMI与MAFLD相关的各种风险因素之间的关联。使用多因素逻辑回归模型研究SUA/Cr或TyG-BMI与MAFLD之间的关系。此外，应用受限立方样条（RCS）和受试者工作特征（ROC）曲线分析来探讨SUA/Cr与MAFLD之间的关系。构建中介模型以确定TyG-BMI在SUA/Cr与MAFLD关联中的中介作用。
Spearman相关性分析显示SUA/Cr与MAFLD的多个风险因素（如BMI、收缩压、舒张压、甘油三酯、总胆固醇、谷丙转氨酶、谷草转氨酶、γ-谷氨酰转肽酶、空腹血糖和高密度脂蛋白）之间存在显著关联。此外，SUA/Cr与TyG-BMI呈正相关（<0.05）。逻辑模型表明，即使在调整混杂因素后，SUA/Cr水平升高也与MAFLD风险增加显著相关（比值比[OR]：1.390；95%置信区间[CI]：1.255 - 1.538）。RCS曲线显示SUA/Cr水平与MAFLD发生之间的关系呈一致且单调增加。此外，SUA/Cr在识别MAFLD个体方面表现出中等鉴别能力（曲线下面积：0.669）。中介分析表明，SUA/Cr与MAFLD之间约52.05%的正相关由TyG-BMI介导。
我们的研究结果表明，中国成年人群中SUA/Cr水平升高与MAFLD风险增加之间存在显著关联，TyG-BMI介导了这种相关性。
