Yang Na-Na, Yang Jing-Wen, Tan Chun-Xia, Li Yue-Jie, Wang Yu, Qi Ling-Yu, Liu Cun-Zhi
International Acupuncture and Moxibustion Innovation Institute, School of Acupuncture-Moxibustion and Tunia, Beijing University of Chinese Medicine, Beijing, China.
Evid Based Complement Alternat Med. 2022 Jan 31;2022:1614648. doi: 10.1155/2022/1614648. eCollection 2022.
Postprandial distress syndrome (PDS) is accompanied by a high incidence of mood disorder. Acupuncture is an effective method in relieving dyspepsia symptoms; however, the impact of psychological status on acupuncture for PDS remains mysterious.
This secondary analysis of a multicenter, randomized controlled trial aims to evaluate the influence of anxiety and depression on acupuncture for PDS. 138 patients received the same acupuncture treatment and were followed up until week 16. The 2 primary outcomes were the response rate based on overall treatment effect and the elimination rate of all 3 cardinal symptoms after 4 weeks of treatment.
Of 114 patients, 31 were anxiety patients and 83 were nonanxiety patients or 32 were depressive patients and 82 were nondepressive patients. The response rate and elimination rate at week 4 were 77.4% and 9.7% in anxiety patients versus 84.3% and 27.7% in nonanxiety patients, respectively ( = 0.388; = 0.041). No significant difference was noted in the response rate ( = 0.552) and elimination rate ( = 0.254) at week 4 between nondepressive and depressive patients. There was no significant intergroup difference in the response rate and elimination rate between non-mood-disorder and mood disorder patients ( > 0.05) during the 12-week post-treatment follow-up, except for the response rate at week 8 ( < 0.05).
The effect of acupuncture on response rate was similar for both non-mood-disorder and mood disorder patients. However, anxiety but not depression had a negative influence on the elimination rate, especially in postprandial fullness.
餐后不适综合征（PDS）常伴有高发性情绪障碍。针灸是缓解消化不良症状的有效方法；然而，心理状态对PDS针灸治疗的影响仍不清楚。
本多中心随机对照试验的二次分析旨在评估焦虑和抑郁对PDS针灸治疗的影响。138例患者接受相同的针灸治疗，并随访至第16周。2个主要结局指标为基于总体治疗效果的有效率和治疗4周后3种主要症状的消除率。
114例患者中，焦虑患者31例，非焦虑患者83例；或抑郁患者32例，非抑郁患者82例。焦虑患者第4周的有效率和消除率分别为77.4%和9.7%，非焦虑患者分别为84.3%和27.7%（=0.388；=0.041）。非抑郁患者和抑郁患者第4周的有效率（=0.552）和消除率（=0.254）无显著差异。在治疗后12周的随访中，非情绪障碍患者和情绪障碍患者之间的有效率和消除率无显著组间差异（>0.05），但第8周的有效率除外（<0.05）。
针灸对非情绪障碍患者和情绪障碍患者有效率的影响相似。然而，焦虑而非抑郁对消除率有负面影响，尤其是对餐后饱胀感。
