Khalil Khaoula, Lahlimi Fatima Ezzahra, Tazi Illias
Department of Hematology and Bone Marrow Transplantation, Mohammed VI University Hospital, Cadi Ayyad University, Marrakesh 40080, Morocco.
Case Rep Gastrointest Med. 2022 Jan 31;2022:2242768. doi: 10.1155/2022/2242768. eCollection 2022.
Solitary extramedullary plasmacytoma (SEP) is a rare neoplasm that is derived from monoclonal proliferation of plasma cells in the soft tissues or organs arising outside the bone marrow. It is present in about 3% of all plasma cell tumors and originates mainly from the upper respiratory tract and nasopharynx. Involvement of the esophagus is exceptionally seen in cases of SEP. . We report a novel case of a 74-year-old male patient attended with a 6-month history of hiccupping further associated with dysphasia and weight loss all caused by esophageal plasmacytoma. Histological and immunohistochemical examination of the tumor confirmed the diagnosis of plasmacytoma. Workup for the multiple myeloma came out to be negative, thus confirming the diagnosis of SEP. The patient was treated with radiotherapy alone, leading to complete remission (at 30 months of follow-up).
Esophageal plasmacytoma, an exceptional presentation of extramedullary plasmacytoma, should be kept in mind while dealing with patients presenting with intractable hiccups.
孤立性髓外浆细胞瘤（SEP）是一种罕见的肿瘤，它源自骨髓外软组织或器官中浆细胞的单克隆增殖。它约占所有浆细胞肿瘤的3%，主要起源于上呼吸道和鼻咽部。SEP病例中罕见食管受累情况。我们报告一例新病例，一名74岁男性患者，有6个月的呃逆病史，进一步伴有吞咽困难和体重减轻，均由食管浆细胞瘤引起。对肿瘤进行组织学和免疫组化检查确诊为浆细胞瘤。多发性骨髓瘤检查结果为阴性，从而确诊为SEP。该患者仅接受放疗，治疗后完全缓解（随访30个月）。
在处理顽固性呃逆患者时，应考虑到食管浆细胞瘤这种髓外浆细胞瘤的特殊表现。
