Kolb H, Zielasek J, Treichel U, Freytag G, Wrann M, Kiesel U
Eur J Immunol. 1986 Feb;16(2):209-12. doi: 10.1002/eji.1830160218.
Treatment of BB rats with recombinant interleukin 2 (IL2) enhanced the development of spontaneous diabetes in these animals. A dose of 20 micrograms IL 2/kg body weight was administered twice daily for 80 days starting at 42 days of age. The rate of diabetes was doubled after IL 2 administration (53% vs. 23%) and the onset of diabetes was found to be accelerated by a mean of 18 days. Histological analysis showed enhanced inflammation of islets and in addition interstitial pancreatis. It is concluded that IL 2 has a regulatory effect on spontaneous organ-specific autoimmunity.
用重组白细胞介素2（IL-2）治疗BB大鼠可加速这些动物自发性糖尿病的发展。从42日龄开始，每天两次给予20微克IL-2/千克体重，持续80天。给予IL-2后糖尿病发生率翻倍（53%对23%），且糖尿病发病平均提前了18天。组织学分析显示胰岛炎症增强，此外还有间质性胰腺炎。结论是IL-2对自发性器官特异性自身免疫有调节作用。
