Ertaş Öztürk Yasemin, Helvaci Elif Merve, Sökülmez Kaya Pınar, Terzi Murat
Department of Nutrition and Dietetics, Faculty of Health Sciences, Ondokuz Mayıs University, Samsun, Turkey.
Department of Neurology, Faculty of Medicine, Ondokuz Mayıs University, Samsun, Turkey.
Nutr Neurosci. 2023 Mar;26(3):228-234. doi: 10.1080/1028415X.2022.2034241. Epub 2022 Feb 10.
Nutrition modulation can reduce multiple sclerosis (MS) related symptoms and fatigue severity. Mediterranean diet may be beneficial regarding anti-inflammatory components. However, previous studies are limited. This study aims to investigate the relationship between Mediterranean diet adherence and MS-related symptoms and fatigue severity.
One hundred and two adult MS patients were enrolled in this cross-sectional study. Dietary adherence was assessed using the Mediterranean diet assessment tool (MEDAS). MS-related symptoms were determined using the MS-related symptom checklist (MS-RS), and the fatigue severity scale (FSS) was applied. Linear regression models were established to assess predicted factors of MS-RS and FSS.
The mean age of the participants was 33.1 ± 9.81 years. Being female and having higher education degree was 71.6% and 60.8%, respectively. In the linear regression model, MEDAS were not associated with MS-RS but negatively associated with FSS scores. MS-RS scores were significantly higher among participants who consumed more than one serving of red meat or products per day. Those who consumed less than one serving of butter, margarine, or cream per day reported lower FSS scores. Some trend significances were shown to consume limited sweet and lower FSS scores. Likewise, MS-RS scores were lower in those ≥three serving/week intake of fish.
Following a Mediterranean-style diet should be encouraged to improve fatigue severity. Components, such as reduced consumption of red meat, saturated fatty acids, sweets and increased fish consumption, could be promising to reduce MS symptoms or fatigue severity. These findings should be proven with further intervention studies.
营养调节可减轻多发性硬化症（MS）相关症状及疲劳严重程度。地中海饮食因其抗炎成分可能有益。然而，既往研究有限。本研究旨在探讨地中海饮食依从性与MS相关症状及疲劳严重程度之间的关系。
102例成年MS患者纳入本横断面研究。采用地中海饮食评估工具（MEDAS）评估饮食依从性。使用MS相关症状清单（MS-RS）确定MS相关症状，并应用疲劳严重程度量表（FSS）。建立线性回归模型以评估MS-RS和FSS的预测因素。
参与者的平均年龄为33.1±9.81岁。女性占71.6%，受过高等教育的占60.8%。在线性回归模型中，MEDAS与MS-RS无关，但与FSS评分呈负相关。每天食用超过一份红肉或其制品的参与者中，MS-RS评分显著更高。每天食用少于一份黄油、人造黄油或奶油的参与者报告的FSS评分较低。食用甜食受限与较低的FSS评分之间显示出一些趋势显著性。同样，每周摄入鱼类≥三份的参与者中，MS-RS评分较低。
应鼓励遵循地中海式饮食以改善疲劳严重程度。减少红肉、饱和脂肪酸、甜食的摄入以及增加鱼类消费等饮食成分，有望减轻MS症状或疲劳严重程度。这些发现应通过进一步的干预研究加以证实。
