Atherosclerosis Unit, Internal Medicine Department, Hospital Carlos III, Madrid 28029, Spain.
Lipid Laboratory, IIS-Fundación Jiménez Díaz, UAM, Madrid 28040, Spain.
Nutrients. 2018 Mar 20;10(3):379. doi: 10.3390/nu10030379.
Adherence to a Mediterranean diet seems to be inversely associated with C-reactive protein (CRP) concentration. A 14-point Mediterranean Diet Adherence Screener (MEDAS) has been developed to assess dietary compliance. The aim of this study was to assess whether each of the MEDAS questions as well as their final score were associated with the levels of CRP in general Spanish population.
Cross-sectional analysis of 1411 subjects (mean age 61 years, 43.0% males) randomly selected from the general population. CRP levels were determined by a commercial ELISA kit. Adherence to the Mediterranean diet was measured by the 14-point MEDAS. There was an inverse correlation between adherence to the Mediterranean diet and the CRP concentration, even after adjusting by age, gender, hypertension, metabolic syndrome, body mass index, statin treatment and hypertension treatment ( = 0.041). Subjects who consume ≥2 servings of vegetables per day ( = 0.003), ≥3 pieces of fruit per day ( = 0.003), ≥1 serving of butter, margarine, or cream per day ( = 0.041) or ≥3 servings of fish/seafood per week ( = 0.058) had significantly lower levels of CRP. : Adherence to a Mediterranean-type diet measured by a simple questionnaire is associated with lower CRP concentration. However, this association seems to be particularly related to a higher consumption of vegetables, fruits, dairy products, and fish.
评估 MEDAS 中的每个问题及其最终得分是否与一般西班牙人群的 CRP 水平相关。
从一般人群中随机抽取 1411 名受试者（平均年龄 61 岁，43.0%为男性）进行横断面分析。通过商业 ELISA 试剂盒测定 CRP 水平。采用 14 分 MEDAS 评估地中海饮食的依从性。
即使在调整年龄、性别、高血压、代谢综合征、体重指数、他汀类药物治疗和高血压治疗后，地中海饮食的依从性与 CRP 浓度呈负相关（ = 0.041）。每天食用≥2 份蔬菜（ = 0.003）、≥3 份水果（ = 0.003）、≥1 份黄油、人造黄油或奶油（ = 0.041）或每周食用≥3 份鱼/海鲜（ = 0.058）的受试者 CRP 水平显著降低。
通过简单问卷测量的地中海饮食模式与 CRP 浓度降低相关。然而，这种关联似乎与蔬菜、水果、乳制品和鱼类的摄入量较高有关。
