Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Chronobiol Int. 2022 Jun;39(6):792-804. doi: 10.1080/07420528.2022.2035392. Epub 2022 Feb 10.
Impulsivity is a multidimensional construct with well-documented risk for substance use problems at both the trait- and state levels. A circadian preference towards eveningness has been linked to trait-level, global impulsivity, but whether this association holds true across multiple dimensions of impulsivity and whether actual sleep timing shows parallel associations with impulsivity remain unclear. Here, we extend existing literature by investigating whether eveningness is associated with multiple facets of both trait- and state-level impulsivity. We also examined these associations utilizing daily measures of sleep timing and duration and explored whether they differed by sex and/or race. All participants were moderate-to-heavy social drinkers aged 21-35. Primary analyses included 78 participants (100% White male participants: Sample 1) with circadian preference data (Composite Scale of Morningness: CSM) and sleep timing (midsleep) and duration assessed via daily self-report over 10 days. Five facets of impulsivity were assessed via the UPPS-P, both at baseline (full scale; trait-level) and up to 6 times per day over 10 days (reduced scale; state-level). Linear regression and mixed-effects models were used to examine between- and within-person associations of impulsivity with measures of circadian preference, timing, and duration, accounting for covariates. Exploratory analyses combined Sample 1 with an additional more diverse sample (Sample 2), resulting in a total of 182 participants (29.1% self-identified as Black, 29.7% as female) with daily self-report sleep timing and duration only (no circadian preference). Primary between-person models found that eveningness was associated with multiple facets of impulsivity, at trait (lack of perseverance) and state levels (negative and positive urgency, lack of perseverance, and lack of premeditation), while average midsleep and duration were generally unrelated to impulsivity. Primary within-person models largely paralleled the between-person findings. Exploratory analyses in the larger combined Samples 1 and 2 (without circadian preference) found that later midsleep timing was associated with greater mean state-level impulsivity across multiple facets, associations that may differ by race and sex. In a sample of White male participants, circadian preference for eveningness was strongly associated with multiple facets of impulsivity, at both trait- and state-levels, which may contribute to risk for substance use. Preliminary findings suggest sex and race differences in sleep-impulsivity associations, but future research with objective sleep/circadian measures in larger, more diverse samples will be important to clarify implications for sleep-focused prevention and/or treatment of substance use.
冲动性是一个多维度的结构,在特质和状态水平上都有充分记录的物质使用问题风险。对夜间型的昼夜节律偏好与特质水平的整体冲动性有关,但这种关联是否适用于冲动性的多个维度,以及实际的睡眠时间是否与冲动性有平行关联尚不清楚。在这里,我们通过调查夜间型是否与特质和状态水平冲动性的多个方面有关,扩展了现有文献。我们还利用每日的睡眠时间和持续时间来检查这些关联,并探讨它们是否因性别和/或种族而有所不同。所有参与者都是 21-35 岁的中度至重度社交饮酒者。主要分析包括 78 名参与者(100%为白人男性参与者:样本 1),他们有昼夜节律偏好数据(综合晨暮量表:CSM)和睡眠时间(午夜)和持续时间,通过 10 天的每日自我报告进行评估。冲动性的五个方面通过 UPPS-P 进行评估,包括基线(全量表;特质水平)和 10 天内每天最多 6 次(简化量表;状态水平)。线性回归和混合效应模型用于检查冲动性与昼夜节律偏好、时间和持续时间的个体间和个体内关联,同时考虑了协变量。探索性分析将样本 1 与另一个更加多样化的样本(样本 2)结合在一起,总共包括 182 名参与者(29.1%自我认定为黑人,29.7%为女性),仅进行每日自我报告的睡眠时间和持续时间(无昼夜节律偏好)。主要的个体间模型发现,夜间型与冲动性的多个方面有关,包括特质(缺乏毅力)和状态水平(消极和积极冲动、缺乏毅力和缺乏深思熟虑),而平均午夜和持续时间通常与冲动性无关。主要的个体内模型在很大程度上与个体间的发现相吻合。在样本 1 和 2(无昼夜节律偏好)的更大组合样本中进行的探索性分析发现,较晚的午夜时间与多个方面的更高的平均状态水平冲动性有关,这些关联可能因种族和性别而异。在一个白种男性参与者的样本中,对夜间型的昼夜节律偏好与特质和状态水平的多个方面的冲动性强烈相关,这可能会增加物质使用的风险。初步研究结果表明,睡眠与冲动性之间存在性别和种族差异,但未来在更大、更多样化的样本中使用客观的睡眠/昼夜节律测量进行研究将有助于澄清对以睡眠为重点的预防和/或物质使用治疗的影响。
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