Siddiqui W A, Tam L Q, Kan S C, Kramer K J, Case S E, Palmer K L, Yamaga K M, Hui G S
Infect Immun. 1986 Apr;52(1):314-8. doi: 10.1128/iai.52.1.314-318.1986.
Monoclonal antibodies to the major Plasmodium falciparum merozoite surface coat and rhoptry antigens were produced. A combination of the affinity-purified polypeptides with Freund complete adjuvant which was given three times completely protected an Aotus lemurinus azure (karotype VI) monkey against homologous challenge; however, immunization with the same polypeptides with a muramyl dipeptide derivative [MDP-Lys(L18)] did not protect a second Aotus monkey, even though comparable high antibody titers were induced.
制备了针对恶性疟原虫裂殖子主要表面被膜和棒状体抗原的单克隆抗体。将亲和纯化的多肽与弗氏完全佐剂联合使用，对一只青猴（核型VI）进行三次注射后，该猴对同源攻击具有完全的保护作用；然而，用相同的多肽与一种胞壁酰二肽衍生物[MDP-Lys(L18)]进行免疫，尽管诱导了相当高的抗体滴度，但并未保护第二只青猴。
