Rubinstein E, Mark Z, Keren G, Alkan M, Berger S, Bogokowski B
Infection. 1986;14 Suppl 1:S20-5. doi: 10.1007/BF01645193.
The in vitro activity of ofloxacin, a new quinolone derivative, was compared to that of other agents commonly in use against pathogens isolated in the community and in the hospital. None of the community or hospital strains isolated from urinary tract infection showed resistance to ofloxacin, while variable resistance was demonstrable with all other oral agents. Similar results were obtained with pathogens isolated from infected wounds originating in the community and in the hospital. Among pathogens isolated from the respiratory tract, ofloxacin was most active against Haemophilus influenzae, but less active than the penicillin-cephalosporin group against Streptococcus pneumoniae. Ofloxacin was active against all but one (Pseudomonas aeruginosa) blood culture isolates. Of 112 strains isolated from community-acquired infections, only one strain was ofloxacin-resistant while resistance to sulphamethoxazole-trimethoprim, ampicillin and doxycycline was 34%, 42% and 30%, respectively. Among 219 pathogens originating from nosocomial infections, 3.2% were resistant to ofloxacin compared to 56% for cefazolin, to 7.2% for cefotaxime, 15.8% for piperacillin and 22.3% for gentamicin. These results suggest that ofloxacin has great therapeutic potential for the therapy of bacterial infections originating both in the community and in the hospital.
将新喹诺酮衍生物氧氟沙星的体外活性与其他常用于治疗社区和医院分离出的病原体的药物进行了比较。从尿路感染中分离出的社区或医院菌株中，没有一株对氧氟沙星耐药，而所有其他口服药物均表现出不同程度的耐药性。从社区和医院来源的感染伤口中分离出的病原体也得到了类似的结果。在从呼吸道分离出的病原体中，氧氟沙星对流感嗜血杆菌的活性最强，但对肺炎链球菌的活性低于青霉素 - 头孢菌素组。除了一株（铜绿假单胞菌）血培养分离株外，氧氟沙星对所有血培养分离株均有活性。在从社区获得性感染中分离出的112株菌株中，只有一株对氧氟沙星耐药，而对磺胺甲恶唑 - 甲氧苄啶、氨苄西林和多西环素的耐药率分别为34%、42%和30%。在219株医院感染源的病原体中，3.2%对氧氟沙星耐药，而头孢唑林的耐药率为56%，头孢噻肟为7.2%，哌拉西林为15.8%，庆大霉素为22.3%。这些结果表明，氧氟沙星在治疗社区和医院来源的细菌感染方面具有巨大的治疗潜力。
