Wise R, Andrews J M, Danks G
J Antimicrob Chemother. 1984 Mar;13(3):237-44. doi: 10.1093/jac/13.3.237.
The in-vitro activity of enoxacin (CI-919), a new synthetic quinoline derivative was compared with that of three other quinolines ofloxacin, norfloxacin and nalidixic acid. In addition beta-lactams and gentamicin were also included when appropriate. The MICs of enoxacin for 90% of Escherichia coli, Klebsiella spp., Enterobacter spp., Proteus spp., Providencia stuartii, Pseudomonas aeruginosa and Staphylococcus aureus were less than 4 mg/l, for Haemophilus influenzae less than 0.25 mg/l and Neisseria gonorrhoeae less than 0.03 mg/l. Bacteroides fragilis and streptococci (including Streptococcus pneumoniae) were less susceptible, MIC90 16 mg/l. Against many of the common Enterobacteriaceae enoxacin displayed a similar degree of activity as gentamicin. Gentamicin-resistant strains of common bacterial pathogens were susceptible to enoxacin as were methicillin-resistant Staph. aureus. The protein binding of enoxacin (concentration 5 mg/l) was 18%.
对新型合成喹啉衍生物依诺沙星（CI - 919）的体外活性与其他三种喹啉类药物氧氟沙星、诺氟沙星和萘啶酸进行了比较。此外，还在适当情况下纳入了β - 内酰胺类药物和庆大霉素。依诺沙星对90%的大肠杆菌、克雷伯菌属、肠杆菌属、变形杆菌属、斯氏普罗威登斯菌、铜绿假单胞菌和金黄色葡萄球菌的最低抑菌浓度（MIC）低于4mg/L，对流感嗜血杆菌低于0.25mg/L，对淋病奈瑟菌低于0.03mg/L。脆弱拟杆菌和链球菌（包括肺炎链球菌）的敏感性较低，MIC90为16mg/L。依诺沙星对许多常见肠杆菌科细菌的活性程度与庆大霉素相似。常见细菌病原体的庆大霉素耐药菌株对依诺沙星敏感，耐甲氧西林金黄色葡萄球菌也对依诺沙星敏感。依诺沙星（浓度5mg/L）的蛋白结合率为18%。
