描述一组急性弛缓性脊髓炎（AFM）患儿的骨骼健康变化。
Description of Bone Health Changes in a Cohort of Children With Acute Flaccid Myelitis (AFM).
机构信息
Arizona College of Osteopathic Medicine, Glendale, Arizona.
Johns Hopkins School of Medicine, Baltimore, Maryland.
出版信息
Top Spinal Cord Inj Rehabil. 2022 Winter;28(1):42-52. doi: 10.46292/sci21-00035. Epub 2022 Jan 19.
OBJECTIVES
To qualitatively describe bone health changes in children with acute flaccid myelitis (AFM) and assess relationships with muscle mass and strength and functional performance.
METHODS
Retrospective analysis of a cohort of 79 children with AFM seen consecutively in one specialized academic center between January 1, 2007, and December 31, 2019.
RESULTS
Of the 79 participants who were aged 4 months to 21 years old, 41 (52%) had bone density measured by dual energy absorptiometry (DXA) and 32 of them (78%) were diagnosed with low bone mass (LBM). We recorded 25 fractures that occurred after onset of neurologic deficit in 14 of the children in the cohort (18%). Lean muscle mass correlated with bone mass and functional performance as assessed by Physical Abilities and Mobility Scale (PAMS) but not with muscle strength as assessed by manual muscle testing (MMT). Bone density in the lower limbs was associated with ambulatory status.
CONCLUSION
Children with AFM have a high likelihood of muscle and bone loss and frequently sustain pathologic fractures. Bone health in children with AFM should be carefully monitored, and efforts should be made to preserve bone mass and maximize muscle mass.
目的
定性描述急性弛缓性脊髓炎（AFM）患儿的骨骼健康变化，并评估其与肌肉量和力量以及功能表现的关系。
方法
回顾性分析了 2007 年 1 月 1 日至 2019 年 12 月 31 日期间在一家专门的学术中心连续就诊的 79 例 AFM 患儿的队列。
结果
在 79 名年龄在 4 个月至 21 岁之间的参与者中，有 41 人（52%）接受了双能 X 线吸收法（DXA）测量骨密度，其中 32 人（78%）被诊断为低骨量（LBM）。我们记录了在队列中的 14 名儿童（18%）神经功能缺损后发生的 25 处骨折。瘦体重与骨量和身体能力和移动量表（PAMS）评估的功能表现相关，但与手动肌肉测试（MMT）评估的肌肉力量无关。下肢骨密度与步行状态有关。
结论
患有 AFM 的儿童肌肉和骨量丢失的可能性较高，经常发生病理性骨折。应密切监测 AFM 患儿的骨骼健康，并努力保持骨量和最大限度地增加肌肉量。
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