Khajavirad Nasim, Salehi Mohammadreza, Haji Ghadery Abdolkarim, Khalili Hossein, Arab Ahmadi Mehran, Dehghan Manshadi Seyed Ali, Zare Dehnavi Ali
Internal Medicine Department Imam Khomeini Hospital Complex Tehran University of Medical Sciences Tehran Iran.
Infectious Diseases and Tropical Medicines Department Tehran University of Medical Sciences Tehran Iran.
Clin Case Rep. 2022 Feb 6;10(2):e05390. doi: 10.1002/ccr3.5390. eCollection 2022 Feb.
In 2020, the SARS-COV-2 disease (COVID-19) imposed huge challenges on the health, economic, and political systems, and by the end of the year, hope had been born with the release of COVID-19 vaccines aimed at bringing the pandemic to an end. However, the COVID-19 vaccination programs have sparked several concerns and ongoing debates over safety issues. Here, we presented three cases of patients with serious adverse events, encephalopathy, vaccine-induced thrombotic thrombocytopenia, and leukocytoclastic vasculitis, after receiving the ChAdOx1 nCoV-19 vaccine. Therefore, it is critical to investigate and report the occurrence of adverse reactions following vaccination, particularly serious ones, as it contributes to the growing body of research and assists clinicians in better diagnosing and managing them.
2020年，严重急性呼吸综合征冠状病毒2（SARS-CoV-2）疾病（新冠肺炎）给健康、经济和政治体系带来了巨大挑战，到当年年底，随着旨在终结疫情的新冠疫苗的推出，希望诞生了。然而，新冠疫苗接种计划引发了一些关于安全问题的担忧和持续辩论。在此，我们介绍了3例在接种牛津大学/阿斯利康公司的ChAdOx1 nCoV-19疫苗后出现严重不良事件的患者病例，这些不良事件包括脑病、疫苗诱导的血栓性血小板减少症和白细胞破碎性血管炎。因此，调查和报告疫苗接种后不良反应的发生情况，尤其是严重不良反应，至关重要，因为这有助于增加研究积累，并协助临床医生更好地诊断和处理这些不良反应。
